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Serotype and clonal distribution dynamics of invasive pneumococcal strains after PCV13 introduction (2011-2016): surveillance data from 23 sites in Catalonia, Spain
(Public Library of Science, 2020-02)
Background: The objective of this study is to describe incidence and shifts of serotype and clonal distribution of invasive Streptococcus pneumoniae strains in four different age groups (<5 years, 5–17 ...
Nasopharyngeal microbiota in children with invasive pneumococcal disease: identification of bacteria with potential disease-promoting and protective effects
(Frontiers Media, 2019)
Background and Aims: The risk of suffering from some infectious diseases can be related to specific microbiota profiles. Specifically, the nasopharyngeal microbiota could play a role as a risk or ...
Reduction of direct health costs associated with pertussis vaccination with acellular vaccines in children aged 0–9 years with pertussis in Catalonia (Spain)
(Springer Nature, 2019)
Objectives: The aim of this study was to assess direct health costs in children with pertussis aged 0–9 years who were vaccinated, partially vaccinated, and unvaccinated during childhood, and to assess ...
Validation of a loop-mediated isothermal amplification assay for rapid diagnosis of invasive pneumococcal disease
(Frontiers Media, 2020-03-24)
Current molecular PCR-based techniques used for detecting Streptococcus pneumoniae, the causative pathogen of invasive pneumococcal disease (IPD), are accurate but have a run time of several hours. We ...
Cerebrospinal fluid neopterin as a biomarker of neuroinflammatory diseases
(Springer Nature, 2020)
The elevation of neopterin in cerebrospinal fluid (CSF) has been reported in several neuroinflammatory disorders. However, it is not expected that neopterin alone can discriminate among different ...
Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era
(Cambridge University Press, 2020-11)
The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study ...
Molecular epidemiology of an enterovirus A71 outbreak associated with severe neurological disease, Spain, 2016
(European Centre for Disease Prevention and Control (ECDC), 2019-02)
Enterovirus 71 (EV-A71) is a small, non-enveloped, single-stranded RNA virus that belongs to the species Enterovirus A along with 24 other serotypes within the Enterovirus genus [1]. According to the ...
Pneumococcal nasopharyngeal carriageamong Bhutanese children hospitalizedwith clinical pneumonia: serotypes andviral co-infection
(Springer Nature, 2020-12)
Background: Pneumococcal nasopharyngeal colonization (PNC) generally precedes pneumococcal disease. The purpose of this study was to determine the prevalence of PNC and to identify the pneumococcal ...
Rapid identification, capsular typing and molecular characterization of streptococcus pneumoniae by using whole genome nanopore sequencing
(Springer Nature, 2020)
Background: Whole genome sequencing has emerged as a useful tool for identification and molecular characterization of pathogens. MinION (Oxford Nanopore) is a real-time third generation sequencer whose ...
Genomic and serologic characterization ofenterovirus A71 brainstem encephalitis
(Wolters Kluwer, 2020)
Objective: In 2016, Catalonia experienced a pediatric brainstem encephalitis outbreak caused by enterovirus A71 (EV-A71). Conventional testing identified EV in the periphery but rarely in CSF. Metagenomic ...