Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era
Author
Izquierdo, Conchita
Ciruela, Pilar
Hernández, Sergi
García-García, Juan José
Esteva, Cristina
Moraga-Llop, Fernando
Díaz-Conradi, A.
Martínez-Osorio, Johanna
Solé-Ribalta, Anna
De Sevilla, Mariona F.
González-Peris, Sebastià
Codina, Gemma
Planes, Ana María
Uriona, Sonia
Campins, Magda
Salleras, Luis
Domínguez, Ángela
Publication date
2020-11ISSN
0950-2688
Abstract
The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study (January 2012–June 2016). IPD cases were diagnosed by culture and/or real-time polymerase chain reaction (PCR). Demographic, microbiological and clinical data were analysed. Associations were assessed using the odds ratio (OR) and 95% confidence intervals (CI). Of the 253 cases, 34.4% were aged <2 years, 38.7% 2–4 years and 26.9% 5–17 years. Over 64% were 13-valent pneumococcal conjugate vaccine (PCV13) serotypes. 48% of the cases were diagnosed only by real-time PCR. Serotypes 3 and 1 were associated with complicated pneumonia (P < 0.05) and non-PCV13 serotypes with meningitis (OR 7.32, 95% CI 2.33–22.99) and occult bacteraemia (OR 3.6, 95% CI 1.56–8.76). Serotype 19A was more frequent in children aged <2 years and serotypes 3 and 1 in children aged 2–4 years and 5–17 years, respectively. 36.1% of cases were not susceptible to penicillin and 16.4% were also non-susceptible to cefotaxime. Serotypes 14, 24F and 23B were associated with non-susceptibility to penicillin (P < 0.05) and serotypes 11, 14 and 19A to cefotaxime (P < 0.05). Serotype 19A showed resistance to penicillin (P = 0.002). In conclusion, PCV13 serotypes were most frequent in children aged ⩽17 years, mainly serotypes 3, 1 and 19A. Non-PCV13 serotypes were associated with meningitis and occult bacteraemia and PCV13 serotypes with pneumonia. Non-susceptibility to antibiotics of non-PCV13 serotypes should be monitored.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
61 - Medical sciences
Keywords
Infants -- Salut i higiene
Pneumococs
Vacunes
Penicil·lina
Niños -- Salud e Higiene
Streptococcus pneumoniae
Vacunas
Penicilina
Children -- Health and hygiene
Pneumococcus
Vaccines
Penicillin
Pages
12
Publisher
Cambridge University Press
Collection
148;
Is part of
Epidemiology and Infection
Citation
Izquierdo, C.; Ciruela, P.; Hernández, S. [et al.]. Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era. Epidemiology and Infection, 2020, 148, e279. Disponible en: <https://www.cambridge.org/core/journals/epidemiology-and-infection/article/pneumococcal-serotypes-in-children-clinical-presentation-and-antimicrobial-susceptibility-in-the-pcv13-era/AE1B808500024D32F81D250C12155339#>. Fecha de acceso: 12 feb. 2021. DOI: 10.1017/ S0950268820002708
This item appears in the following Collection(s)
- Ciències de la Salut [740]
Rights
© The Author(s), 2020. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/