Listando Departament de Ciències Bàsiques (Biomedicina, Bioenginyeria, Psicologia) por título
Mostrando ítems 6-25 de 51
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CDK-mediated phosphorylation of Yku80 and its role in DNA repair
(Fecha de defensa: 2021-03-11)DNA double-strand breaks (DSBs) are considered the most deleterious lesions of DNA and they are repaired by means of two main mechanisms: homologous recombination (HR) and non-homologous endjoining ... -
Characterization of new mutations in transferrin, DMT1 and SEC23B causing rare iron metabolism-related diseases; and the discovery of RACGAP1 as the gene responsible for autosomal recessive congenital dyserythropoietic anaemia type III
(Fecha de defensa: 2023-11-25)Iron is a biometal involved in many physiological processes that are essential for life. Iron metabolism is a complex and tightly regulated process both at the systemic and cellular level. Proper iron ... -
Control de la estabilidad de ciclinas de G1 por nutrientes
(Fecha de defensa: 2014-07-31)El control del ciclo celular está altamente regulado mediante diferentes CDKs asociadas a ciclinas. En Saccharomyces cerevisiae, la CDK esencial Cdc28 es la que regula mayoritariamente este proceso. En ... -
CPT1C and endocannabinoids as hypothalamic players in early stages of obesity development
(Fecha de defensa: 2019-12-10)Obesity prevalence in worldwide population is increasing every day due to an imbalance between the energy intake and the energy expenditure. Rich-caloric food is highly palatable and easily accessible, ... -
CPT1c in specific hypothalamic nuclei and its role in lipid sensing and metabolic adaptation
(Fecha de defensa: 2022-09-23)Obesity has become a pandemic disease in the last 40 years. The WHO estimates that the population with overweight has nearly tripled since 1975, and the tendency is still growing. These data have an ... -
CPT1C-ABHD6 interaction in hypothalamic neurons: implications for bis (monoacylglycero) phosphate metabolism and the endolysosomal system
(Fecha de defensa: 2024-02-14)El sistema endolisosomal juga un paper crític en la funció neuronal i ha emergit com a un potencial objectiu per al tractament de diverses malalties neuronals, com els trastorns neurodegeneratius i fins ... -
CPT1C-dependent regulation of GluA1 trafficking under metabolic stress
(Fecha de defensa: 2019-12-10)Carnitine palmitoyltransferase 1C (CPT1C) is the brain-specific isoform of the CPT1 family which is located at the endoplasmic reticulum (ER) of neurons and exhibits low catalytic activity, but still ... -
Desarrollo de nuevos métodos para el análisis del polifosfato en células humanas
(Fecha de defensa: 2023-11-20)Nombre / Nom / Name Ana Apellidos / Cognoms / Surname Sarrias Giménez Dirección de correo electrónico / Adreça de correu electrònic / email address (opcional / optional) anasargim@gmail.com Departamento ... -
Development of C75-CoA loaded polymeric micelles targeting brain CPT1A: A novel nanomedicine-based approach to fight obesity and cancer
(Fecha de defensa: 2024-02-14)Brain lipid metabolism has a key role in many physiological processes, and its malfunction is associated with a plethora of diseases, such as obesity and glioblastoma multiforme (GBM). Carnitine palmitoyl ... -
Development of novel bioinks formulations based on supramolecular self-assembled hydrogels for tissue regeneration.
(Fecha de defensa: 2023-05-16)The field of tissue engineering relies on the use of biomaterials as scaffolds for tissue and organ regeneration. If properly designed, these scaffolds can mimic the in vivo microenvironment while also ... -
Development of sol-gel silica-based 3D printable materials with tunable degradation, mechanical properties and drug release capacity for tissue engineering
(Fecha de defensa: 2023-05-31)The bone is a very complex organ that participates in multiple critical functions for the human body. Bone can be affected by different health issues, such as physical trauma or tumor, and the body ... -
El polifosfat és un element clau durant la replicació del DNA.
(Fecha de defensa: 2015-11-06)Throughout its lifespan, eukaryotic cells steadily consume free cytoplasmic orthophosphate to produce phospholipids and mRNA. However, during DNA synthesis, in a matter of minutes, cells require large ... -
Estudi de la ciclina atípica CCNI com a potencial activador de CDK6 en línies de càncer de mama
(Fecha de defensa: 2022-02-09)Fa quasi 40 anys del descobriment de les ciclines, les proteïnes oscil·lants tradicionalment dividies en dos grups, “cicle cel·lular” i “ciclines transcripcionals”, que duen a terme els seus rols juntament ... -
Evaluation of biomarkers for studying new challenges in tobacco control
(Fecha de defensa: 2023-12-19)El tabaquismo es reconocido a nivel global como un factor de riesgo significativo para la salud pública y una de las principales causas de muertes prevenibles. España ha implementado políticas de control ... -
Evaluation of the impact of Spanish smoking legislation on tobacco consumption and passive exposure
(Fecha de defensa: 2018-03-14)In Spain, two smoke-free laws have been passed after the approval of the FCTC. In 2005, it came into effect a smoke-free legislation (Law 28/2005). This law was a great advance for public health in ... -
Expresión de factores de transcripción TCF7L2 durante la diferenciación in vitro de células de neuroblastoma inducida por el ácido retinoico.
(Fecha de defensa: 2018-02-06)Las proteínas TCF7L2 (transcription factor 7-like 2) son un conjunto de factores de transcripción que participan en la vía Wnt y son responsables, entre otras funciones, del mantenimiento de las células ... -
Extracellular UTP signalling in Schwann cell migration: A novel role of the P2Y2 receptor
(Fecha de defensa: 2013-09-24)Peripheral neuropaties are one of the major complications of the Peripheral Nervous System. Depsite the big importance of those pathologies, less drugs are effective for their treatment, and most of the ... -
Factores relacionados con el perdón: características de la ofensa, del ofensor y del ofendido.
(Fecha de defensa: 2016-03-01)En el presente trabajo revisamos las diferentes variables que han sido asociadas al perdón. Son muchos los factores que influyen en que dicho proceso se lleve a cabo o no. Estudios previos han ... -
G1-Cdk modulation by time and stress
(Fecha de defensa: 2022-09-23)The cell cycle is regulated at different layers of control in either homeostatic or non-homeostatic conditions. Hence, in this work we analyse how time and stress modulate the cell cycle through the ... -
Hypothalamic Ceramide Levels regulated by CPT1C mediate the Orexigenic effect of Ghrelin
(Fecha de defensa: 2014-07-31)Recent data suggest that ghrelin exerts its orexigenic action through regulation of hypothalamic AMP-activated protein kinase pathway, leading to a decline in malonyl-CoA levels and desinhibition of ...