Recerca: Recent submissions
Now showing items 401-420 of 2974
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Venture Capital, the Regions and Public Policy: The United Kingdom since the Post-2000 Technology Crash
(Regional Studies, 2013)Mason C. and Pierrakis Y. Venture capital, the regions and public policy: the United Kingdom since the post-2000 technology crash, Regional Studies. The geography of venture capital in the United Kingdom ... -
Venture Capital in Crisis: The Impact of the Economic Downturn in Company’s Time to Exit
(The Journal of Alternative Investments Winter, 2013)The collapse of many IT-related companies shocked venture capital investors around the world in 2000–2001. Similarly, the 2008–2009 financial crisis found VC investors very vulnerable. This article ... -
Public Policies and Public Programs with a Regional Impact in Promoting Entrepreneurship: The Case Study of Government Backed Venture Capital Schemes in the UK
(2016)This chapter adds to the growing literature from recent years on innovation finance, innovation systems, and regional economic policy. Although the role of business has been seen as critical within the ... -
Dimensional changes of the carpal tunnel and median nerve during manual mobilization of the carpal bones - Anatomical study
(Clinical Biomechanics, 2018)Study design: Cross-sectional study. Background: The carpal tunnel is a clinically important fibro-osseous conduit for the median nerve and associated tendons. It is mechanically dynamic and therapeutic ... -
Do publicly backed venture capital investments promote innovation? Differences between privately and publicly backed funds in the UK venture capital market
(Journal of Business Venturing Insights, 2017)This paper examines the link between publicly backed venture capital funds and business innovation in the UK venture capital market. In examining this relationship, the research empirically analyses the ... -
The role of venture capitalists in the regional innovation ecosystem: a comparison of networking patterns between private and publicly backed venture capital funds
(The Journal of Technology Transfer, 2019)This paper empirically examines the development of social networks among venture capitalists and other professionals of the regional innovation ecosystem. Using an online survey of venture capitalists, ... -
Control of cell cycle progression by the stress-activated Hog1 MAPK
(Cell Cycle, 2005)Activation of the stress-activated Hog1 kinase is essential for cell survival in response to high osmolarity. The Hog1 SAPK elicits the program for cell adaptation that includes modulation of several ... -
Posttranscriptional control and the role of RNA-binding proteins in gene regulation in trypanosomatid protozoan parasites
(WIREs RNA, 2010)Trypanosomatids are unicellular eukaryotes responsible for severe diseases in humans. They exhibit a number of remarkable biological phenomena, especially at the RNA level. During their life cycles, ... -
Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma brucei
(PLOS One, 2012)Regulation of RNA polymerase II transcription initiation is apparently absent in trypanosomes. Instead, these eukaryotes control gene expression mainly at the post-transcriptional level. Regulation is ... -
A short RNA stem–loop is necessary and sufficient for repression of gene expression during early logarithmic phase in trypanosomes
(Nucleic Acids Research, 2014)We have compared the transcriptomes of cultured procyclic Trypanosoma brucei cells in early and late logarithmic phases and found that ∼200 mRNAs were differentially regulated. In late log phase cells, ... -
Depletion of the RNA-binding protein RBP33 results in increased expression of silenced RNA polymerase II transcripts in trypanosoma brucei
(PLOS One, 2014)We have characterized the RNA-binding protein RBP33 in Trypanosoma brucei, and found that it localizes to the nucleus and is essential for viability. The subset of RNAs bound to RBP33 was determined by ... -
Meet the players: local translation at the synapse
(Frontiers in Molecular Neuroscience, 2014)It is widely believed that activity-dependent synaptic plasticity is the basis for learning and memory. Both processes are dependent on new protein synthesis at the synapse. Here, we describe a mechanism ... -
CLIPing Staufen to secondary RNAstructures: Size and location matter!
(BioEssays, 2015)hiCLIP (RNA hybrid and individual-nucleotide resolution ultraviolet cross-linking and immunoprecipitation), is a novel technique developed by Sugimoto et al. (2015). Here, the use of different adaptors ... -
RNA transport: from head to toe in radial glial cells
(Current Biology, 2016)Intracellular mRNA localization critically contributes to proper brain development and function. A recent study demonstrates that mRNAs are actively transported in radial glial cells from the soma to ... -
A retained intron in the 3′‐UTR of Calm3 mRNA mediates its Staufen2‐ and activity‐dependent localization to neuronal dendrites
(EMBO Reports, 2017)Dendritic localization and hence local mRNA translation contributes to synaptic plasticity in neurons. Staufen2 (Stau2) is a well‐known neuronal double‐stranded RNA‐binding protein (dsRBP) that has been ... -
Forebrain-specific, conditional silencing of Staufen2 alters synaptic plasticity, learning, and memory in rats
(Genome Biology, 2017)Background: Dendritic messenger RNA (mRNA) localization and subsequent local translation in dendrites critically contributes to synaptic plasticity and learning and memory. Little is known, however, ... -
The alternative life of RNA—sequencing meets single molecule approaches
(FEBS Letters, 2017)The central dogma of RNA processing has started to totter. Single genes produce a variety of mRNA isoforms by mRNA modification, alternative polyadenylation (APA), and splicing. Different isoforms, even ... -
Recruitment of Staufen2 Enhances Dendritic Localization of an Intron-Containing CaMKIIα mRNA
(Cell Reports, 2017)Regulation of mRNA localization is a conserved cellular process observed in many types of cells and organisms. Asymmetrical mRNA distribution plays a particularly important role in the nervous system, ... -
Professional competence, personal occupational well-being, and mental workload of nurse educators – A cross-sectional study in four European countries
(Nurse Education Today, 2024)Background: Nurse educators need a high level of professional competence to educate future health care professionals. Professional competence supports occupational well-being whilst high mental workload ... -
An integrative review of the continuing professional development needs for nurse educators
(Nurse Education Today, 2023)Objectives: The study aimed at describing the field of research in continuing professional development for nurse educators and the continuous education and development needs of nurse educators by asking: ...