Biomimetic mineralized hybrid scaffolds with antimicrobial peptides
Autor/a
Ye, Zhou
Zhu, Xiao
Mutreja, Isha
Kumar Boda, Sunil
Fischer, Nicholas G.
Zhang, Anqi
Lui, Christine
Qi, Yipin
Data de publicació
2021-08ISSN
2452-199X
Resum
Infection in hard tissue regeneration is a clinically-relevant challenge. Development of scaffolds with dual function for promoting bone/dental tissue growth and preventing bacterial infections is a critical need in the field. Here we fabricated hybrid scaffolds by intrafibrillar-mineralization of collagen using a biomimetic process and subsequently coating the scaffold with an antimicrobial designer peptide with cationic and amphipathic properties. The highly hydrophilic mineralized collagen scaffolds provided an ideal substrate to form a dense and stable coating of the antimicrobial peptides. The amount of hydroxyapatite in the mineralized fibers modulated the rheological behavior of the scaffolds with no influence on the amount of recruited peptides and the resulting increase in hydrophobicity. The developed scaffolds were potent by contact killing of Gram-negative Escherichia coli and Gram-positive Streptococcus gordonii as well as cytocompatible to human bone marrow-derived mesenchymal stromal cells. The process of scaffold fabrication is versatile and can be used to control mineral load and/or intrafibrillar-mineralized scaffolds made of other biopolymers.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
616.3 - Patologia de l'aparell digestiu. Odontologia
Paraules clau
Mineralització biomimètica
Antimicrobiana
Pèptids catiònics i amfipàtics
Citocompatibilitat del teixit dur
Mineralización biomimética
Antimicrobiano
Péptidos catiónicos y anfipáticos
Citocompatibilidad de tejido duro
Biomimetic mineralization
Antimicrobial
Cationic and amphipathic peptides
Hard tissue cytocompatibility
Pàgines
11
Publicat per
Elsevier
Col·lecció
6; 8
Publicat a
Bioactive Materials
Citació
Ye, Zhou; Zhu, Xiao; Mutreja, Isha [et al.]. Biomimetic mineralized hybrid scaffolds with antimicrobial peptides. Bioactive Materials, 2021, 6(8), p. 2250-2260. Disponible en: <https://www.sciencedirect.com/science/article/pii/S2452199X21000037>. Fecha de acceso: 20 abr. 2023. DOI: 10.1016/j.bioactmat.2020.12.029
Enllaç al document relacionat
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Odontologia [245]
Drets
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com https://creativecommons.org/licenses/by-nc-nd/4.0/