Association of nine pathobionts with periodontitis in four South American and European countries
Author
Contreras, María José
Mendoza, Gerardo
Nart, Jose
Publication date
2023ISSN
2000-2297
Abstract
Aim: Our aim was to compare the prevalence and load of nine pathobionts in subgingival samples of healthy individuals and periodontitis patients from four different countries. Methods: Five hundred and seven subgingival biofilm samples were collected from healthy subjects and periodontitis patients in Belgium, Chile, Peru and Spain. The prevalence and load of Eubacterium brachy, Filifactor alocis, Fretibacterium fastidiosum, Porphyromonas endodontalis, Porphyromonas gingivalis, Selenomonas sputigena, Treponema denticola, Tannerella forsythia and Treponema socranskii were measured by quantitative PCR. Results: The association with periodontitis of all species, except for T. socranskii, was confirmed in all countries but Peru, where only P. endodontalis, P. gingivalis and T. denticola were found to be significantly associated. Moreover, most species showed higher loads at greater CAL and PPD, but not where there was BOP. Through Principal Component Analysis, samples showed clearly different distributions by diagnosis, despite observing a smaller separation in Peruvian samples. Conclusions: Unlike prevalence, relative load was found to be a reliable variable to discriminate the association of the species with periodontitis. Based on this, F. alocis, P. endodontalis, P. gingivalis, T. denticola and T. forsythia may be biomarkers of disease in Belgium, Chile and Spain, due to their significantly higher abundance in periodontitis patients.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
616.3 - Pathology of the digestive system. Complaints of the alimentary canal
Keywords
Càrrega bacteriana
Biomarcador
Patobiont
Prevalença
PCR quantitativa
Especificitat d'espècie
Carga bacteriana
Biomarcador
Patobionte
Predominio
PCR cuantitativa
Especificidad de especie
Bacterial load
Biomarker
Pathobiont
Prevalence
Quantitative PCR
Species specificity
Pages
10
Publisher
Journal of Oral Microbiology
Collection
15
Is part of
Journal of Oral Microbiology
Citation
Àlvarez Juste, Gerard; Arredondo, Alexandre; Isabal Pueyo, Sergio [et al.]. Association of nine pathobionts with periodontitis in four South American and European countries. Journal of Oral Microbiology, 2023, 15(1), 2188630. Disponible en: <https://www.tandfonline.com/doi/full/10.1080/20002297.2023.2188630>. Fecha de acceso: 31 mar. 2023. DOI: 10.1080/20002297.2023.2188630
Link to the related item
This item appears in the following Collection(s)
- Odontologia [248]
Rights
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc/4.0/