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dc.contributor.authorGiordano-Kelhoffer, Barbara
dc.contributor.authorRodríguez-Gonzalez, Raquel
dc.contributor.authorPerpiñan-Blasco, Marina
dc.contributor.authorOlmos Buitrago, Jennifer
dc.contributor.authorBosch Canals, Begoña Maria
dc.contributor.authorPerez, Roman
dc.date.accessioned2023-01-11T08:47:06Z
dc.date.available2023-01-11T08:47:06Z
dc.date.issued2023
dc.identifier.citationGiordano-Kelhoffer, Barbara; Rodríguez-Gonzalez, Raquel; Perpiñan-Blasco, Marina [et al.]. A novel chitosan composite biomaterial with drug eluting capacity for maxillary bone regeneration. Materials, 2023, 16(2), 685. Disponible en: <https://www.mdpi.com/1996-1944/16/2/685>. Fecha de acceso: 11 ene. 2023. DOI: 10.3390/ma16020685ca
dc.identifier.issn1996-1944ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/3528
dc.description.abstractBone grafting is one of the most commonly performed treatments for bone healing or repair. Autografts, grafts from the same patient, are the most frequently used bone grafts because they can provide osteogenic cells and growth factors at the site of the implant with reduced risk of rejection or transfer of diseases. Nevertheless, this type of graft presents some drawbacks, such as pain, risk of infection, and limited availability. For this reason, synthetic bone grafts are among the main proposals in regenerative medicine. This branch of medicine is based on the development of new biomaterials with the goal of increasing bone healing capacity and, more specifically in dentistry, they aim at simultaneously preventing or eliminating bacterial infections. The use of fibers made of chitosan (CS) and hydroxyapatite (HA) loaded with an antibiotic (doxycycline, DX) and fabricated with the help of an injection pump is presented as a new strategy for improving maxillary bone regeneration. In vitro characterization of the DX controlled released from the fibers was quantified after mixing different amounts of HA (10–75%). The 1% CS concentration was stable, easy to manipulate and exhibited adequate cuttability and pH parameters. The hydroxyapatite concentration dictated the combined fast and controlled release profile of CSHA50DX. Our findings demonstrate that the CS-HA-DX complex may be a promising candidate graft material for enhancing bone tissue regeneration in dental clinical practice.en
dc.format.extent14ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofMaterialsca
dc.relation.ispartofseries16;2
dc.relation.urihttps://www.mdpi.com/1996-1944/16/2/685ca
dc.rights© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.otherEmpelt ossica
dc.subject.otherQuitosàca
dc.subject.otherHidroxiapatitaca
dc.subject.otherDoxiciclinaca
dc.subject.otherInjerto óseoes
dc.subject.otherQuitosanoes
dc.subject.otherHidroxiapatitaes
dc.subject.otherDoxiciclinaes
dc.subject.otherBone graften
dc.subject.otherChitosanen
dc.subject.otherHydroxyapatiteen
dc.subject.otherDoxycyclineen
dc.titleA novel chitosan composite biomaterial with drug eluting capacity for maxillary bone regenerationen
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc61ca
dc.subject.udc616.7ca
dc.identifier.doihttps://dx.doi.org/10.3390/ma16020685ca


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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Excepto si se señala otra cosa, la licencia del ítem se describe como https://creativecommons.org/licenses/by/4.0/
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