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Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants
dc.contributor.author | Toledano-Serrabona, Jorge | |
dc.contributor.author | Bosch Canals, Begoña Maria | |
dc.contributor.author | Díez-Tercero, Leire | |
dc.contributor.author | Gil Mur, Francisco Javier | |
dc.contributor.author | Camps Font, Octavi | |
dc.contributor.author | Valmaseda-Castellon, Eduard | |
dc.contributor.author | Gay Escoda, Cosme | |
dc.contributor.author | Sánchez-Garcés, Mª Ángeles | |
dc.date.accessioned | 2022-10-20T15:02:21Z | |
dc.date.available | 2022-10-20T15:02:21Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Toledano-Serrabona, Jorge; Bosch Canals, Begoña Maria; Díez-Tercero, Leire [et al.]. Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants. Scientific Reports, 2022, 12, 15790. Disponible en: <https://www.nature.com/articles/s41598-022-20100-2>. Fecha de acceso: 20 oct. 2022. DOI: 10.1038/s41598-022-20100-2 | ca |
dc.identifier.issn | 2045-2322 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/3460 | |
dc.description.abstract | Implantoplasty is a mechanical decontamination technique that consists of removing the threads and polishing and smoothing the dental implant surface. During implantoplasty there is a large release of titanium metal particles that might provoke a proinflammatory response and reduce the viability of osteogenic cells. We analyze the inflammatory and osteogenic response induced by Ti6Al4V particles released during implantoplasty and by as-received commercially pure Ti particles. Macrophages stimulated with metal particles obtained by implantoplasty and with as-received Ti particles showed an increased proinflammatory expression of TNF-α and a decreased expression of TGF-β and CD206. Regarding cytokine release, there was an increase in IL-1β, while IL-10 decreased. The osteogenic response of Ti6Al4V extracts showed a significant decrease in Runx2 and OC expression compared to the controls and commercially pure Ti extracts. There were no relevant changes in ALP activity. Thus, implantoplasty releases metal particles that seems to induce a pro-inflammatory response and reduce the expression of osteogenic markers. | en |
dc.format.extent | 11 | ca |
dc.language.iso | eng | ca |
dc.publisher | Springer Nature | ca |
dc.relation.ispartof | Scientific Reports | ca |
dc.relation.ispartofseries | 12 | |
dc.relation.uri | https://www.nature.com/articles/s41598-022-20100-2 | ca |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Implants dentals | ca |
dc.subject.other | Periimplantitis | ca |
dc.subject.other | Implantes dentales | es |
dc.subject.other | Periimplantitis | es |
dc.subject.other | Dental implants | en |
dc.subject.other | Peri-implantitis | en |
dc.title | Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 616.3 | ca |
dc.identifier.doi | https://dx.doi.org/10.1038/s41598-022-20100-2 | ca |
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Odontologia [242]