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dc.contributor.authorQuandt Herrera, Eva
dc.contributor.authorRibeiro, Mariana P. C.
dc.contributor.authorClotet Erra, Josep
dc.date.accessioned2021-09-13T16:34:26Z
dc.date.available2021-09-13T16:34:26Z
dc.date.issued2020
dc.identifier.citationQuandt Herrera, Eva; Ribeiro, Mariana P. C.; Clotet, Josep. Atypical cyclins: the extended family portrait. Cellular and Molecular Life Sciences, 2020, 77, p. 231-242. Disponible en: <https://link.springer.com/article/10.1007%2Fs00018-019-03262-7>. Fecha de acceso: 13 sep. 2021. DOI: 10.1007/s00018-019-03262-7ca
dc.identifier.issn1420-682Xca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/2781
dc.description.abstractRegulation of cell division is orchestrated by cyclins, which bind and activate their catalytic workmates, the cyclin-dependent kinases (CDKs). Cyclins have been traditionally defined by an oscillating (cyclic) pattern of expression and by the presence of a characteristic “cyclin box” that determines binding to the CDKs. Noteworthy, the Human Genome Sequence Project unveiled the existence of several other proteins containing the “cyclin box” domain. These potential “cyclins” have been named new, orphan or atypical, creating a conundrum in cyclins nomenclature. Moreover, although many years have passed after their discovery, the scarcity of information regarding these possible members of the family has hampered the establishment of criteria for systematization. Here, we discuss the criteria that define cyclins and we propose a classification and nomenclature update based on structural features, interactors, and phylogenetic information. The application of these criteria allows to systematically define, for the first time, the subfamily of atypical cyclins and enables the use of a common nomenclature for this extended family.en
dc.format.extent12ca
dc.language.isoengca
dc.publisherSpringer Natureca
dc.relation.ispartofCellular and Molecular Life Sciencesca
dc.relation.ispartofseries77;
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherFosforilacióca
dc.subject.otherCicle cel·lularca
dc.subject.otherFamília de ciclinesca
dc.subject.otherCanònicca
dc.subject.otherTranscripcionalca
dc.subject.otherFosforilaciónes
dc.subject.otherCiclo celulares
dc.subject.otherFamilia ciclinaes
dc.subject.otherCanónicoes
dc.subject.otherTranscripcionales
dc.subject.otherPhosphorylationen
dc.subject.otherCell cycleen
dc.subject.otherCyclin familyen
dc.subject.otherCanonicalen
dc.subject.otherTranscriptionalen
dc.titleAtypical cyclins: the extended family portraiten
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc61ca
dc.identifier.doihttps://dx.doi.org/10.1007/s00018-019-03262-7ca


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This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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