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dc.contributor.authorArredondo, Alexandre
dc.contributor.authorBlanc, Vanessa
dc.contributor.authorMor Reinoso, Carolina
dc.contributor.authorNart Molina, José
dc.contributor.authorLeón, Rubén
dc.date.accessioned2021-06-04T17:18:36Z
dc.date.available2021-06-04T17:18:36Z
dc.date.issued2020
dc.identifier.citationArredondo, Alexandre; Blanc, Vanessa; Mor, Carolina [et al.]. Tetracycline and multidrug resistance in the oral microbiota: differences between healthy subjects and patients with periodontitis in Spain. Journal of Oral Microbiology, 2020, 13, 1847431. Disponible en: <https://www.tandfonline.com/doi/full/10.1080/20002297.2020.1847431>. Fecha de acceso: 4 jun. 2021. DOI: 10.1080/20002297.2020.1847431ca
dc.identifier.issn2000-2297ca
dc.identifier.urihttp://hdl.handle.net/20.500.12328/2599
dc.description.abstractIntroduction: Antibiotic resistance is widely found even among bacterial populations not having been exposed to selective pressure by antibiotics, such as tetracycline. In this study we analyzed the tetracycline-resistant subgingival microbiota of healthy subjects and of patients with periodontitis, comparing the prevalence of tet genes and their multidrug resistance profiles. Methods: Samples from 259 volunteers were analyzed, obtaining 813 tetracycline-resistant isolates. The prevalence of 12 antibiotic resistance genes was assessed, and multidrug profiles were built. Each isolate was identified by 16S rRNA sequencing. Differences in qualitative data and quantitative data were evaluated using the chi-square test and the Mann-Whitney-U test, respectively. Results: tet(M) was the most frequently detected tet gene (52.03%). We observed significant differences between the prevalence of tet(M), tet(W), tet(O), tet(32) and tet(L) in both populations studied. Multidrug resistance was largely observed, with resistance to kanamycin being the most detected (83.64%). There were significant differences between the populations in the prevalence of kanamycin, chloramphenicol, and cefotaxime resistance. Resistant isolates showed significantly different prevalence between the two studied groups. Conclusion: The high prevalence of multidrug resistance and tetracycline resistance genes found in the subgingival microbiota, highlights the importance of performing wider and more in-depth analysis of antibiotic resistance in the oral microbiota.en
dc.format.extent10ca
dc.language.isoengca
dc.publisherTaylor & Francisca
dc.relation.ispartofJournal of Oral Microbiologyca
dc.relation.ispartofseries13;1
dc.rights© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subject.otherResistència als antibiòticsca
dc.subject.otherAntibiòticsca
dc.subject.otherTetraciclinaca
dc.subject.otherPeriodontitisca
dc.subject.otherMicrobiota subgingivalca
dc.subject.otherResistència a múltiples fàrmacsca
dc.subject.otherResistencia a los antibióticoses
dc.subject.otherAntibióticoses
dc.subject.otherTetraciclinaes
dc.subject.otherPeriodontitises
dc.subject.otherMicrobiota subgingivales
dc.subject.otherResistencia a múltiples fármacoses
dc.subject.otherAntibiotic resistanceen
dc.subject.otherAntibioticsen
dc.subject.otherTetracyclineen
dc.subject.otherPeriodontitisen
dc.subject.otherSubgingival microbiotaen
dc.subject.otherResistance to multiple drugsen
dc.titleTetracycline and multidrug resistance in the oral microbiota: differences between healthy subjects and patients with periodontitis in Spainen
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc616.3ca
dc.identifier.doihttps://doi.org/10.1080/20002297.2020.1847431ca


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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/3.0/