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Tetracycline and multidrug resistance in the oral microbiota: differences between healthy subjects and patients with periodontitis in Spain
dc.contributor.author | Arredondo, Alexandre | |
dc.contributor.author | Blanc, Vanessa | |
dc.contributor.author | Mor Reinoso, Carolina | |
dc.contributor.author | Nart Molina, José | |
dc.contributor.author | León, Rubén | |
dc.date.accessioned | 2021-06-04T17:18:36Z | |
dc.date.available | 2021-06-04T17:18:36Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Arredondo, Alexandre; Blanc, Vanessa; Mor, Carolina [et al.]. Tetracycline and multidrug resistance in the oral microbiota: differences between healthy subjects and patients with periodontitis in Spain. Journal of Oral Microbiology, 2020, 13, 1847431. Disponible en: <https://www.tandfonline.com/doi/full/10.1080/20002297.2020.1847431>. Fecha de acceso: 4 jun. 2021. DOI: 10.1080/20002297.2020.1847431 | ca |
dc.identifier.issn | 2000-2297 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/2599 | |
dc.description.abstract | Introduction: Antibiotic resistance is widely found even among bacterial populations not having been exposed to selective pressure by antibiotics, such as tetracycline. In this study we analyzed the tetracycline-resistant subgingival microbiota of healthy subjects and of patients with periodontitis, comparing the prevalence of tet genes and their multidrug resistance profiles. Methods: Samples from 259 volunteers were analyzed, obtaining 813 tetracycline-resistant isolates. The prevalence of 12 antibiotic resistance genes was assessed, and multidrug profiles were built. Each isolate was identified by 16S rRNA sequencing. Differences in qualitative data and quantitative data were evaluated using the chi-square test and the Mann-Whitney-U test, respectively. Results: tet(M) was the most frequently detected tet gene (52.03%). We observed significant differences between the prevalence of tet(M), tet(W), tet(O), tet(32) and tet(L) in both populations studied. Multidrug resistance was largely observed, with resistance to kanamycin being the most detected (83.64%). There were significant differences between the populations in the prevalence of kanamycin, chloramphenicol, and cefotaxime resistance. Resistant isolates showed significantly different prevalence between the two studied groups. Conclusion: The high prevalence of multidrug resistance and tetracycline resistance genes found in the subgingival microbiota, highlights the importance of performing wider and more in-depth analysis of antibiotic resistance in the oral microbiota. | en |
dc.format.extent | 10 | ca |
dc.language.iso | eng | ca |
dc.publisher | Taylor & Francis | ca |
dc.relation.ispartof | Journal of Oral Microbiology | ca |
dc.relation.ispartofseries | 13;1 | |
dc.rights | © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | |
dc.subject.other | Resistència als antibiòtics | ca |
dc.subject.other | Antibiòtics | ca |
dc.subject.other | Tetraciclina | ca |
dc.subject.other | Periodontitis | ca |
dc.subject.other | Microbiota subgingival | ca |
dc.subject.other | Resistència a múltiples fàrmacs | ca |
dc.subject.other | Resistencia a los antibióticos | es |
dc.subject.other | Antibióticos | es |
dc.subject.other | Tetraciclina | es |
dc.subject.other | Periodontitis | es |
dc.subject.other | Microbiota subgingival | es |
dc.subject.other | Resistencia a múltiples fármacos | es |
dc.subject.other | Antibiotic resistance | en |
dc.subject.other | Antibiotics | en |
dc.subject.other | Tetracycline | en |
dc.subject.other | Periodontitis | en |
dc.subject.other | Subgingival microbiota | en |
dc.subject.other | Resistance to multiple drugs | en |
dc.title | Tetracycline and multidrug resistance in the oral microbiota: differences between healthy subjects and patients with periodontitis in Spain | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 616.3 | ca |
dc.identifier.doi | https://doi.org/10.1080/20002297.2020.1847431 | ca |
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Odontologia [245]