Mostra el registre parcial de l'element
Is systemic inflammation a missing link between periodontitis and hypertension? Results from two largepopulation-based surveys
dc.contributor.author | Muñoz Aguilera, E. | |
dc.contributor.author | Leira, Y. | |
dc.contributor.author | Miró Catalina, Queralt | |
dc.contributor.author | Orland, M. | |
dc.contributor.author | Czesnikiewicz-Guzik, Marta | |
dc.contributor.author | Guzik, T. J. | |
dc.contributor.author | Hingorani, A. D. | |
dc.contributor.author | Nart Molina, José | |
dc.contributor.author | D’Aiuto, F. | |
dc.date.accessioned | 2021-05-21T17:40:11Z | |
dc.date.available | 2021-05-21T17:40:11Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Muñoz Aguilera, E.; Leira, Y.; Miró Catalina, Q. [et al.]. Is systemic inflammation a missing link between periodontitis and hypertension? Results from two largepopulation-based surveys. Journal of Internal Medicine, 2020, 289(4), p. 532-546. Disponible en: <https://onlinelibrary.wiley.com/doi/10.1111/joim.13180>. Fecha de acceso: 21 may. 2021. DOI: 10.1111/joim.13180 | ca |
dc.identifier.issn | 1365-2796 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/2558 | |
dc.description.abstract | Objective: The primary objective was to investigate the relationship between periodontitis and hypertension in two independent large surveys. The secondary objective was to ascertain whether systemic inflammation had a mediation effect in the association. Methods: This cross-sectional study analysed representative samples of the US (n = 3460; NHANES 2009/10) and Korean (n = 4539; 2015 KNHANES VI-3) populations. The association between periodontitis (exposure), hypertension (outcome) and inflammatory markers [C-reactive protein (CRP) and white blood cell counts (WBC)] (mediators) was assessed using multivariate linear and logistic regression models and mediation analysis. Results: Participants with periodontitis were more likely to have hypertension (NHANES: OR = 1.3, 95% CI: 1.0–1.6, P = 0.025; KNHANES: OR = 1.2, 95% CI: 1.0–1.4, P = 0.041) and actual systolic blood pressure ≥ 140 mmHg (NHANES: OR = 1.6, 95% CI: 1.1–2.3, P < 0.001; KNHANES: OR = 1.3, 95% CI :1.0–1.6, P < 0.031) than those without the disease. These associations were independent of age, gender, BMI, education level, smoking, alcohol consumption, creatinine, physical activity, presence of other comorbidities and confirmed in participants not taking antihypertensive medications. Diagnosis of periodontitis was directly associated with WBC (in both surveys: NHANES: β ± SE = 0.3 ± 0.1, P < 0.004; KNHANES: β ± SE = 0.3 ± 0.1, P < 0.001) and with CRP levels (in one survey: NHANES: β ± SE = 0.1 ± 0.03, P < 0.007; KNHANES: β ± SE = 0.1 ± 0.04, P > 0.213). Mediation analyses confirmed that CRP acted as a mediator in the association between periodontitis and hypertension in both populations (mediated effect: NHANES: β ± SE = 0.010 ± 0.003, P < 0.001; KNHANES: β ± SE = 0.003 ± 0.001, P = 0.015). WBC acted as a mediator in the KNHANES (mediated effect: β ± SE = 0.004 ± 0.001, P = 0.004) whilst in the NHANES, its effect was dependent of CRP inclusion in the model (mediated effect WBC + CRP: β ± SE = 0.002 ± 0.001, P = 0.001). Conclusions: These findings suggest that periodontitis is closely linked to hypertension and systemic inflammation is, in part, a mediator of this association. | ca |
dc.format.extent | 15 | ca |
dc.language.iso | eng | ca |
dc.publisher | John Wiley & Sons, Inc. | ca |
dc.relation.ispartof | Journal of Internal Medicine | ca |
dc.relation.ispartofseries | 289;4 | |
dc.rights | The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | ca |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject.other | Periodontitis | ca |
dc.subject.other | Hipertensió | ca |
dc.subject.other | Inflamació | ca |
dc.subject.other | Odontologia | ca |
dc.subject.other | Leucòcits | ca |
dc.subject.other | Periodontitis | es |
dc.subject.other | Hipertensión | es |
dc.subject.other | Inflamación | es |
dc.subject.other | Odontología | es |
dc.subject.other | Leucocitos | es |
dc.subject.other | Periodontitis | en |
dc.subject.other | Hypertension | en |
dc.subject.other | Inflammation | en |
dc.subject.other | Dentistry | en |
dc.subject.other | Leukocytes | en |
dc.title | Is systemic inflammation a missing link between periodontitis and hypertension? Results from two largepopulation-based surveys | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.subject.udc | 616.3 | ca |
dc.identifier.doi | https://dx.doi.org/10.1111/joim.13180 | ca |
Fitxers en aquest element
Aquest element apareix en la col·lecció o col·leccions següent(s)
-
Odontologia [245]