• Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol 

      Arnedo, María; Menao, Sebastián; Puisac, Beatriz; Teresa-Rodrigo, María E.; Gil-Rodríguez, María C.; López-Viñas, Eduardo; Gómez-Puertas, Paulino; Casals i Farré, Núria; Casale, César H.; Hegardt, Fausto G.; Pié, Juan (Journal of Lipid Research, 2012)
      A novel lyase activity enzyme is characterized for the first time: HMG-CoA lyase-like1 (er-cHL), which is a close homolog of mitochondrial HMG-CoA lyase (mHL). Initial data show that there are nine ...
    • Eradication of hepatitis C virus and non-liver-related non–acquired immune deficiency syndrome–related events in human immunodeficiency virus/hepatitis C virus coinfection 

      Berenguer, Juan; Rodríguez-Castellano, Elena; Carrero, Ana; Von Wichmann, Miguel A.; Montero, Marta; Galindo, María J.; Mallolas, Josep; Crespo, Manuel; Téllez, María J.; Quereda, Carmen; Sanz, José; Barros, Carlos; Tural, Cristina; Santos, Ignacio; Pulido, Federico; Guardiola Tey, Josep Maria; Rubio, Rafael; Ortega, Enrique; Montes, María L.; Jusdado, Juan J.; Gaspar, Gabriel; Esteban, Herminia; Bellón, José M.; González-García, Juan; GESIDA HIV-HCV Cohort Study Group (Hepatology, 2017)
      We assessed non-liver-related non–acquired immunodeficiency syndrome (AIDS)-related (NLR-NAR) events and mortalityin a cohort of human immunodeficiency virus (HIV)/hepatitis C virus (HCV)–coinfected ...
    • Implication between genetic variants from APOA5 and ZPR1 and NAFLD severity in patients with hypertriglyceridemia 

      Esteve-Luque, Virginia; Padró-Miquel, Ariadna; Fanlo-Maresma, Marta; Corbella, Emili; Corbella Virós, Xavier; Pintó, Xavier; Candás-Estébanez, Beatriz (Nutrients, 2021)
      Background: Lipid metabolism disorders, especially hypertriglyceridemia (HTG), are risk factors for non-alcoholic fatty liver disease (NAFLD). However, the association between genetic factors related ...
    • Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD 

      Weber, Minéia; Mera, Paula; Casas, Josefina; Salvador, Javier; Rodríguez, Amaia; Alonso, Sergio; Sebastián, David; Soler-Vázquez, M. Carmen; Montironi, Carla; Recalde, Sandra; Fucho, Raquel; Calderón-Domínguez, María; Mir, Joan Francesc; Bartrons, Ramon; Escola-Gil, Joan Carles; Sánchez-Infantes, David; Zorzano, Antonio; Llorente-Cortes, Vicenta; Casals i Farré, Núria; Valentí, Víctor; Frühbeck, Gema; Herrero Rodríguez, Laura; Serra, Dolors (Federation of American Societies for Experimental Biology, 2020)
      The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased drastically due to the global obesity pandemic but at present there are no approved therapies. Here, we aimed to revert high‐fat ...