Now showing items 1-6 of 6

    • Current challenges for targeting brown fat thermogenesis to combat obesity 

      Yoneshiro, Takeshi; Rodríguez-Rodríguez, Rosalía; Johannes Betz, Matthias; Rensen, Patrick C. N. (Frontiers in Endocrinology, 2020-10-27)
      Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ...
    • Editorial: current challenges for targeting brown fat thermogenesis to combat obesity 

      Yoneshiro, Takeshi; Rodríguez-Rodríguez, Rosalía; Johannes Betz, Matthias; Rensen, Patrick C. N. (Frontiers in Endocrinology, 2020-10-27)
      Just over a decade has passed since metabolically active brown adipose tissue (BAT) was unequivocally identified in healthy adult humans. Since then, researchers have provided evidence of expression of ...
    • Effects of autologous adipose-derived regenerative stem cells administered at the time of anterior cruciate ligament reconstruction on knee function and graft healing 

      Alentorn-Geli, Eduard; Seijas, Roberto; Martínez-De la Torre, Adrián; Cuscó, Xavier; Steinbacher, Gilbert; Álvarez Díaz, Pedro; Barastegui, David; Navarro, Jordi; Serra Renom, Josep Maria; Nishishinya, Betina; Català, Jordi; Laiz, Patricia; García-Balletbó, Montserrat; Cugat, Ramón (Journal of Orthopaedic Surgery, 2019)
      Purpose: To compare the healing and clinical outcomes of anterior cruciate ligament (ACL) reconstruction between patients with or without intraoperative administration of adipose-derived regenerative ...
    • Hypothalamic AMPK-ER Stress-JNK1 axis mediates the central actions of thyroid hormones on energy balance 

      Martinez-Sanchez, Noelia; Seoane-Collazo, Patricia; Contreras, Cristina; Varela, Luis; Villarroya, Joan; Rial-Pensado, Eva; Buque, Xabier; Aurrekoetxea, Igor; Delgado, Teresa C.; Vazquez-Martinez, Rafael; Gonzalez-Garcia, Ismael; Roa, Juan; Whittle, Andrew J.; Gomez-Santos, Beatriz; Velagapudi, Vidya; Loraine Tung, Y. C.; Morgan, Donald A.; Voshol, Peter J.; Martinez de Morentin, Pablo B.; Lopez-Gonzalez, Tania; Linares-Pose, Laura; Gonzalez, Francisco; Chatterjee, Krishna; Sobrino, Tomas; Medina-Gomez, Gema; Davis, Roger J.; Casals i Farré, Núria; Oresic, Matej; Coll, Anthony P.; Vidal-Puig, Antonio; Mittag, Jens; Tena-Sempere, Manuel; Malagon, Maria M.; Dieguez, Carlos; Martinez-Chantar, Maria Luz; Aspichueta, Patricia; Rahmouni, Kamal; Nogueiras, Rubén; Sabio, Guadalupe; Villarroya, Francesc; Lopez, Miguel (Cell Metabolism, 2017-07)
      Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) ...
    • Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice 

      Miralpeix Monclús, Cristina; Fosch, Anna; Casas, Josefina; Baena, Miguel; Herrero Rodríguez, Laura; Serra, Dolors; Rodríguez-Rodríguez, Rosalía; Casals i Farré, Núria (Journal of Lipid Research, 2019-07)
      The endocannabinoid (eCB) system regulates energy homeostasis and is linked to obesity development. However, the exact dynamic and regulation of eCBs in the hypothalamus during obesity progression remain ...
    • Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice 

      Soler Vázquez, M. Carmen; Romero, María del Mar; Todorcevic, Marijana; Delgado, Katia; Calatayud, Carles; Benitez Amaro, Aleyda; La Chica Lhoëst, Maria Teresa; Mera, Paula; Zagmutt, Sebastián; Bastías Pérez, Marianela; Ibeas, Kevin; Casals, Núria; Escolà Gil, Joan Carles; Llorente Cortés, Vicenta; Consiglio, Antonella; Serra, Dolors; Herrero, Laura (Metabolic Engineering, 2023-05)
      Obesity and its associated metabolic comorbidities are a rising global health and social issue, with novel therapeutic approaches urgently needed. Adipose tissue plays a key role in the regulation of ...