Visualitzant Ciències de la Salut per matèria "ADN--Anàlisi"

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    • Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer 

      Ricco Pacheco, Natalia; Flor, Amy; Wolfgeher, Donald; Efimova, Elena V.; Ramamurthy, Aishwarya; Appelbe, Oliver K.; Brinkman, Jacqueline; Truman, Andrew W.; Spiotto, Michael T.; Kron, Stephen J. (Molecular Oncology, 2019-06-21)
      Radioresistance is a major hurdle in the treatment of head and neck squamous cell carcinoma (HNSCC). Here, we report that concomitant treatment of HNSCCs with radiotherapy and mevalonate pathway inhibitors ...

    • The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage 

      Truman, Andrew W.; Kristjansdottir, Kolbrun; Wolfgeher, Donald; Ricco Pacheco, Natalia; Mayampurath, Anoop; Volchenboum, Samuel L.; Clotet Erra, Josep; Kron, Stephen J. (Data in Brief, 2015-03)
      The molecular chaperones Hsp70 and Hsp90 participate in many important cellular processes, including how cells respond to DNA damage. Here we show the results of applied quantitative affinity-purification ...