Browsing Ciències de la Salut by Author "Kaulich, Manuel"

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    • Functional genomics approaches to elucidate vulnerabilities of intrinsic and acquired chemotherapy resistance 

      Cetin, Ronay; Quandt Herrera, Eva; Kaulich, Manuel (Cells, 2021)
      Drug resistance is a commonly unavoidable consequence of cancer treatment that results in therapy failure and disease relapse. Intrinsic (pre-existing) or acquired resistance mechanisms can be drug-specific ...

    • Optimized metrics for orthogonal combinatorial CRISPR screens 

      Cetin, Ronay; Wegner, Martin; Luwisch, Leah; Saud, Sarada; Achmedov, Tatjana; Süsser, Sebastian; Vera-Guapi, Antonella; Müller, Konstantin; Matthess, Yves; Quandt, Eva; Schaubeck, Simone; Beisel, Chase L.; Kaulich, Manuel (Scientific Reports, 2023)
      CRISPR-based gene perturbation enables unbiased investigations of single and combinatorial genotype-to-phenotype associations. In light of efforts to map combinatorial gene dependencies at scale, choosing ...