Browsing Ciències de la Salut by Author "Gallego, Rosalía"

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    • Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance 

      Contreras, Cristina; González-García, Ismael; Martínez-Sánchez, Noelia; Seoane-Collazo, Patricia; Jacas i Mateu, Jordi; Morgan, Donald A.; Serra, Dolors; Gallego, Rosalía; Gonzalez, Francisco; Casals i Farré, Núria; Nogueiras, Rubén; Rahmouni, Kamal; Diéguez, Carlos; López, Miguel (Cell Reports, 2014-10)
      Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, ...