Articles: Agregados recientemente
Mostrando ítems 401-420 de 2321
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The role of venture capitalists in the regional innovation ecosystem: a comparison of networking patterns between private and publicly backed venture capital funds
(The Journal of Technology Transfer, 2019)This paper empirically examines the development of social networks among venture capitalists and other professionals of the regional innovation ecosystem. Using an online survey of venture capitalists, ... -
Control of cell cycle progression by the stress-activated Hog1 MAPK
(Cell Cycle, 2005)Activation of the stress-activated Hog1 kinase is essential for cell survival in response to high osmolarity. The Hog1 SAPK elicits the program for cell adaptation that includes modulation of several ... -
Posttranscriptional control and the role of RNA-binding proteins in gene regulation in trypanosomatid protozoan parasites
(WIREs RNA, 2010)Trypanosomatids are unicellular eukaryotes responsible for severe diseases in humans. They exhibit a number of remarkable biological phenomena, especially at the RNA level. During their life cycles, ... -
Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma brucei
(PLOS One, 2012)Regulation of RNA polymerase II transcription initiation is apparently absent in trypanosomes. Instead, these eukaryotes control gene expression mainly at the post-transcriptional level. Regulation is ... -
A short RNA stem–loop is necessary and sufficient for repression of gene expression during early logarithmic phase in trypanosomes
(Nucleic Acids Research, 2014)We have compared the transcriptomes of cultured procyclic Trypanosoma brucei cells in early and late logarithmic phases and found that ∼200 mRNAs were differentially regulated. In late log phase cells, ... -
Depletion of the RNA-binding protein RBP33 results in increased expression of silenced RNA polymerase II transcripts in trypanosoma brucei
(PLOS One, 2014)We have characterized the RNA-binding protein RBP33 in Trypanosoma brucei, and found that it localizes to the nucleus and is essential for viability. The subset of RNAs bound to RBP33 was determined by ... -
Meet the players: local translation at the synapse
(Frontiers in Molecular Neuroscience, 2014)It is widely believed that activity-dependent synaptic plasticity is the basis for learning and memory. Both processes are dependent on new protein synthesis at the synapse. Here, we describe a mechanism ... -
CLIPing Staufen to secondary RNAstructures: Size and location matter!
(BioEssays, 2015)hiCLIP (RNA hybrid and individual-nucleotide resolution ultraviolet cross-linking and immunoprecipitation), is a novel technique developed by Sugimoto et al. (2015). Here, the use of different adaptors ... -
RNA transport: from head to toe in radial glial cells
(Current Biology, 2016)Intracellular mRNA localization critically contributes to proper brain development and function. A recent study demonstrates that mRNAs are actively transported in radial glial cells from the soma to ... -
A retained intron in the 3′‐UTR of Calm3 mRNA mediates its Staufen2‐ and activity‐dependent localization to neuronal dendrites
(EMBO Reports, 2017)Dendritic localization and hence local mRNA translation contributes to synaptic plasticity in neurons. Staufen2 (Stau2) is a well‐known neuronal double‐stranded RNA‐binding protein (dsRBP) that has been ... -
Forebrain-specific, conditional silencing of Staufen2 alters synaptic plasticity, learning, and memory in rats
(Genome Biology, 2017)Background: Dendritic messenger RNA (mRNA) localization and subsequent local translation in dendrites critically contributes to synaptic plasticity and learning and memory. Little is known, however, ... -
The alternative life of RNA—sequencing meets single molecule approaches
(FEBS Letters, 2017)The central dogma of RNA processing has started to totter. Single genes produce a variety of mRNA isoforms by mRNA modification, alternative polyadenylation (APA), and splicing. Different isoforms, even ... -
Recruitment of Staufen2 Enhances Dendritic Localization of an Intron-Containing CaMKIIα mRNA
(Cell Reports, 2017)Regulation of mRNA localization is a conserved cellular process observed in many types of cells and organisms. Asymmetrical mRNA distribution plays a particularly important role in the nervous system, ... -
Professional competence, personal occupational well-being, and mental workload of nurse educators – A cross-sectional study in four European countries
(Nurse Education Today, 2024)Background: Nurse educators need a high level of professional competence to educate future health care professionals. Professional competence supports occupational well-being whilst high mental workload ... -
An integrative review of the continuing professional development needs for nurse educators
(Nurse Education Today, 2023)Objectives: The study aimed at describing the field of research in continuing professional development for nurse educators and the continuous education and development needs of nurse educators by asking: ... -
Effects of COVID-19 confinement on the incidence and mortality of major osteoporotic fractures: an observational study in Catalonia, Spain
(Archives of Osteoporosis, 2022)Summary: There is little information on how the COVID-19 lockdown influenced the epidemiology of major osteoporotic fractures (MOF). We analyzed the incidence and mortality of MOF in 2020 compared with ... -
Epidemiology of major osteoporotic fractures: a population-based analysis in Catalonia, Spain
(Archives of Osteoporosis, 2022)Purpose: The aim of this study was to estimate the incidence of major osteoporotic fractures in Catalonia, Spain, in 2018 and 2019 and their association with age, sex, income, climate and a set of ... -
Impact of major osteoporotic fractures on the use of healthcare resources in Catalonia, Spain
(Bone, 2024)Objectives: To estimate the impact of first major osteoporotic fractures (MOF) on health resource use and healthcare expenditures in people aged ≥50 years in Catalonia, Spain. Design: Observational, ... -
Impact of school-based nutrition and physical activity intervention on body mass index eight years after cessation of randomized controlled trial (AVall study)
(Clinical Nutrition, 2019)Background & aims: The prevalence of obesity and overweight among children is increasing, representing a new and pressing societal problem. Excess weight in childhood is an independent risk factor for ... -
Four-year outcomes of an educational intervention in healthy habits in schoolchildren: the Avall 3 Trial
(European Journal of Public Health, 2016)Background: The prevalence of obesity among children is increasing, but treating obesity is difficult and has poor outcomes. We assessed the 4-year impact of a school-based educational intervention on ...