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A two-base deletion in exon 6 of the 3-hydroxy-3- methylglutaryl coenzyme A lyase (HL) gene producing the skipping of exons 5 and 6 determines 3- hydroxy-3-methylglutaric aciduria
(Elsevier, 1997)
A novel two-base deletion in the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene was found in a Spanish patient with homozygous 3-hydroxy-3-methylglutaric aciduria. Amplification by RT-PCR of the ...
Hypothalamic endocannabinoids in obesity: an old story with new challenges
(Springer, 2021)
The crucial role of the hypothalamus in the pathogenesis of obesity is widely recognized, while the precise molecular and cellular mechanisms involved are the focus of intense research. A disrupted ...
Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
(John Wiley & Sons, Inc., 2020)
The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased drastically due to the global obesity pandemic but at present there are no approved therapies. Here, we aimed to revert high‐fat ...
Increased infammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
(Springer Nature, 2017-11-22)
Obesity is associated with severe metabolic diseases such as type 2 diabetes, insulin resistance, cardiovascular disease and some forms of cancer. The pathophysiology of obesity-induced metabolic diseases ...
CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity
(Elsevier, 2019-01)
Objective: Carnitine palmitoyltransferase 1C (CPT1C) is implicated in central regulation of energy homeostasis. Our aim was to investigate whether CPT1C in the ventromedial nucleus of the hypothalamus ...
CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy
(Nature Research, 2018-05-03)
Human mesenchymal stem cells (hMSCs) are widely used in regenerative medicine. In some
applications, they must survive under low nutrient conditions engendered by avascularity. Strategies to
improve ...
Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol
(American Society for Biochemistry and Molecular Biology, 2012)
A novel lyase activity enzyme is characterized for the first time: HMG-CoA lyase-like1 (er-cHL), which is a close homolog of mitochondrial HMG-CoA lyase (mHL). Initial data show that there are nine ...
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition
(American Society for Biochemistry and Molecular Biology, 2003-03-14)
Carnitine palmitoyltransferase (CPT) I, which catalyzes the conversion of palmitoyl-CoA to palmitoylcarnitine facilitating its transport through the mitochondrial membranes, is inhibited by malonyl-CoA. ...
The return of malonyl-CoA to the brain: cognition and other stories
(Elsevier, 2021-01)
Nutrients, hormones and the energy sensor AMP-activated protein kinase (AMPK) tightly regulate the intracel-lular levels of the metabolic intermediary malonyl-CoA, which is a precursor of fatty ...
Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids
(Springer Nature, 2017-09-07)
The grey and white matter regions of the mammalian brain consist of both neurons and neuroglial cells. Among the neuroglia, the two macroglia oligodendrocytes and astrocytes are the most abundant cell ...