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Statins in cancer prevention and therapy
(MDPI, 2023)
Statins, a class of HMG-CoA reductase inhibitors best known for their cholesterol-reducing and cardiovascular protective activity, have also demonstrated promise in cancer prevention and treatment. This ...
Precision and safety of ultrasound-guided versus palpation-guided needle placement on the patellar tendon: a cadaveric study
(MDPI, 2023)
For decades, needling interventions have been performed based on manual palpation and anatomic knowledge. The increasing use of real-time ultrasonography in clinical practice has improved the accuracy ...
CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non-associative learning
(Wiley, 2023)
Carnitine palmitoyltransferase 1c (CPT1C) is a neuron-specific protein widely distributed throughout the CNS and highly expressed in discrete brain areas including the hypothalamus, hippocampus, amygdala ...
What makes the palliative care initial encounter meaningful? A descriptive study with patients with cancer, family carers and palliative care professionals
(Sage Journals, 2023)
Background: The palliative care initial encounter can have a positive impact on the quality of life of patients and family carers if it proves to be a meaningful experience. A better understanding of ...
Heterotopía, multiversos y viajes en el tiempo: la representación de la ciencia en Futurama y en Rick & Morty
(2023)
Esta investigación pretende detectar, codificar y cuantificar los principales temas y problemas científicos presentados en las series animadas de humor adulto Futurama y Rick and Morty con el objetivo ...
Changes in lung function in adolescents with substance use disorders: an exploratory study
(Sociedade Brasileira de Pneumologia e Tisiologia, 2023)
Objective: To compare lung function between adolescents with and without substance use disorder (SUD). Methods: This was an observational, cross-sectional exploratory study. The sample consisted of 16 ...
Iron-regulatory proteins limit hypoxia-inducible factor 2α expression in iron deficiency
(Springer Nature, 2007)
Hypoxia stimulates erythropoiesis, the major iron-utilization pathway. We report the discovery of a conserved, functional iron-responsive element (IRE) in the 5′ untranslated region of the messenger RNA ...
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice
(Springer Nature, 2004)
Inflammation influences iron balance in the whole organism. A common clinical manifestation of these changes is anemia of chronic disease (ACD; also called anemia of inflammation). Inflammation reduces ...
The european hematology association roadmap for european hematology research: a consensus document
(Ferrata Storti Foundation, 2016)
The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical ...
Targeting DNA repair defects for precision medicine in prostate cancer
(Springer Nature, 2019)
Purpose of Review: Genomic studies of localized and metastatic prostate cancer have identified a high prevalence of clinically actionable alterations including mutations in DNA repair genes. In this ...