Browsing Articles by Author "Jenkins, Kirsten"
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Growth rate as a direct regulator of the start network to set cell size
Aldea Malo, Martí; Jenkins, Kirsten; Csikász-Nagy, Attila (Frontiers in Cell and Developmental Biology, 2017-05-26)Cells are able to adjust their growth and size to external inputs to comply with specific fates and developmental programs. Molecular pathways controlling growth also have an enormous impact in cell ... -
Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
Moreno, David F.; Jenkins, Kirsten; Morlot, Sandrine; Charvin, Gilles; Csikász-Nagy, Attila; Aldea Malo, Martí (eLife, 2019-09-13)Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-effect relationships are not well understood. We show that most yeast cells arrest in G1 before death with low ...