A Prospective Double-Blind Placebo Controlled Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia
To access the full text documents, please follow this link: http://hdl.handle.net/10803/403440
Author
Rubina Filipa Ascensão, Alves
Other authors
Grimalt, Ramon
Universitat Internacional de Catalunya. Departament de Medicina
Date of defense
2017-05-25T17:42:38Z2017-05-25T17:42:38Z
2017-02-17
Abstract
Background: Androgenetic Alopecia (AGA) is a nonscarring alopecia that affects both men and women. It is characterized by a progressive miniaturization of hair follicles with a characteristic pattern distribution in genetically predisposed men and women. The currently available treatments for AGA are sometimes perceived as having limited effectiveness, therefore, Platelet-rich plasma (PRP) has been postulated as a new therapy for AGA.
Objective: To assess the efficacy of PRP on the evolution of AGA, between 6 months of treatment and baseline.
Methods: This was a prospective, randomized, placebo controlled, double-blind, half-head study in male and female patients with AGA. The patient selection was performed in two different phases, according to presence or absence of medication for AGA. Group A included patients without previous medication for AGA and Group B included patients under medication for AGA (minoxidil or finasteride). All patients received a total of 3 treatments of PRP on one half-head and saline solution in the other half-head, with an interval of 1 month from each other. Injected areas comprised 4 circular areas marked with a dot tattoo. The follow-up visit was made at 6 months.
Results: In Group A: administration of PRP alone attended a statistically significant improvement of mean hair density, mean terminal hair density, mean anagen hairs and telogen hairs, when compared with baseline, at 6 months. A statistically significantly correlation between demographic data and trichoscan analysis was found with two parameters: mean total hair density and mean anagen hairs. Regarding Group B: administration of PRP associated with ongoing medication is effective on the evolution of AGA. Both minoxidil or finasteride associated with PRP improved hair regrowth, although PRP in combination with minoxidil showed a greater improvement than PRP with finasteride, at six months.
Limitations: The two major limitations of this study relate to the sample size and duration of follow-up.
Conclusion: Administration of autologous PRP had a positive effect on male and female pattern hair loss without major side-effects.
Document Type
Thesis
Published version
Language
English
Subjects and keywords
Alopecia
Androgenetic alopecia
Hair loss
Platelet-rich plasma
Growth factors
Double-blind
Clinical trial
Drug therapy
Humans
Dermatología
616.5
Pages
258 p.
application/pdf
application/pdf
Publisher
Universitat Internacional de Catalunya
This item appears in the following Collection(s)
Rights
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-nd/4.0/