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Browsing by Subject "Proteins"

Now showing items 1-7 of 7

    • Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status 

      Miralpeix Monclús, Cristina; Reguera, Ana Cristina; Fosch, Anna; Casas, Maria; Lillo, Jaume; Navarro, Gemma; Franco, Rafael; Casas, Josefina; Alexander, Stephen P.H.; Casals i Farré, Núria; Rodríguez-Rodríguez, Rosalía (British Journal of Pharmacology, 2021-01)
      Background and Purpose: The enzyme α/β‐hydrolase domain containing 6 (ABHD6), a new member of the endocannabinoid system, is a promising therapeutic target against neuronal‐related diseases. However, ...

    • Computational modeling as a tool to investigate PPI: from drug design to tissue engineering 

      Perez, Juan J.; Pérez Antoñanzas, Roman; Perez, Alberto (Frontiers in Molecular Biosciences, 2021)
      Protein-protein interactions (PPIs) mediate a large number of important regulatory pathways. Their modulation represents an important strategy for discovering novel therapeutic agents. However, the ...

    • Detection and expression analysis of tet(B) in streptococcus oralis 

      Arredondo, Alexandre; Àlvarez, Gerard; Nart Molina, José; Mor Reinoso, Carolina; Blanc, Vanessa; León, Rubén (Journal of Oral Microbiology, 2019)
      Tetracycline resistance can be achieved through tet genes, which code for efflux pumps, ribosomal protection proteins and inactivation enzymes. Some of these genes have only been described in either ...

    • Mechanical and physicochemical characterization along with biological interactions of a new Ti25Nb21Hf alloy for bone tissue engineering 

      Herranz-Diez, Carolina; Gil Mur, Francisco Javier; Guillem Martí, Jordi; Manero Planella, José María (Journal of Biomaterials Applications, 2015-03-23)
      Nowadays, one of the main challenges in metal implants for bone substitution is the achievement of an elastic modulus close to that of human cortical bone as well as to provide an adequate interaction ...

    • Proteasomal-mediated degradation of AKAP150 accompanies AMPAR endocytosis during cLTD 

      Cheng, Wenwen; Siedlecki-Wullich, Dolores; Català-Solsona, Judit; Fábregas, Cristina; Fadó Andrés, Rut; Casals i Farré, Núria; Solé, Montse; Unzeta, Mercedes; Saura, Carlos A.; Rodríguez-Álvarez, José; Miñano Molina, Alfredo Jesús (eNeuro, 2020-03-23)
      The number and function of synaptic AMPA receptors (AMPARs) tightly regulates excitatory synaptic transmission. Current evidence suggests that AMPARs are inserted into the postsynaptic membrane during ...

    • SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2 

      Barroso, Emma; Rodríguez-Rodríguez, Rosalía; Zarei, Mohammad; Pizarro-Delgado, Javier; Planavila, Anna; Palomer, Xavier; Villarroya, Francesc; Vázquez-Carrera, Manuel (Cell Communication and Signaling18;147, 2020-09-10)
      Background: Deficiency of mitochondrial sirtuin 3 (SIRT3), a NAD+-dependent protein deacetylase that maintains redox status and lipid homeostasis, contributes to hepatic steatosis. In this study, we ...

    • Structural (betaalpha) 8 TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase 

      Casals i Farré, Núria; Gómez-Puertas, Paulino; Pié, Juan; Mir, Cecilia; Roca, Ramón; Puisac, Beatriz; Aledo, Rosa; Clotet Erra, Josep; Menao, Sebastián; Serra, Dolors; Asins, Guillermina; Till, Jacqueline; Elias-Jones, Alun C.; Cresto, Juan C.; Chamoles, Nestor A.; Abdenur, Jose E.; Mayatepek, Ertan; Besley, Guy; Valencia, Alfonso; Hegardt, Fausto G. (Journal of Biological Chemistry, 2003)
      This study describes three novel homozygous missense mutations (S75R, S201Y, and D204N) in the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) lyase gene, which caused 3-hydroxy-3-methylglutaric aciduria in ...