Browsing by Subject "Neuroscience"
Now showing items 1-5 of 5
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Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids
(Scientific Reports, 2017-09-07)The grey and white matter regions of the mammalian brain consist of both neurons and neuroglial cells. Among the neuroglia, the two macroglia oligodendrocytes and astrocytes are the most abundant cell ... -
CPT1c in specific hypothalamic nuclei and its role in lipid sensing and metabolic adaptation
(Date of defense: 2022-09-23)Obesity has become a pandemic disease in the last 40 years. The WHO estimates that the population with overweight has nearly tripled since 1975, and the tendency is still growing. These data have an ... -
Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wild-type and fragile X model mice
(Molecular Psychiatry, 2021)Many neurodevelopmental disorders are characterized by impaired functional synaptic plasticity and abnormal dendritic spine morphology, but little is known about how these are related. Previous work in ... -
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking
(Journal of Cell Biology, 2020)Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ... -
Translational research in psychiatry: The Research Domain Criteria Project (RDoC)
(Revista de Psiquiatría y Salud Mental, 2019)Despite the consensus achieved in the homogenisation of clinical criteria by categorical psychiatric classification systems (DEM and CIE), they are criticised for a lack of validity and inability to ...