Browsing by Subject "Neurociència"
Now showing items 1-4 of 4
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Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wild-type and fragile X model mice
(Molecular Psychiatry, 2021)Many neurodevelopmental disorders are characterized by impaired functional synaptic plasticity and abnormal dendritic spine morphology, but little is known about how these are related. Previous work in ... -
Papel de CPT1C en el desarrollo axonal y en el transporte de los endosomas tardíos
(Date of defense: 2018-03-23)La paraplejía espástica hereditaria agrupa un conjunto de desórdenes neurodegenerativos caracterizados por espasticidad y rigidez muscular. Todos ellos están relacionados clínica y patológicamente con ... -
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking
(Journal of Cell Biology, 2020)Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ... -
Translational research in psychiatry: The Research Domain Criteria Project (RDoC)
(Revista de Psiquiatría y Salud Mental, 2019)Despite the consensus achieved in the homogenisation of clinical criteria by categorical psychiatric classification systems (DEM and CIE), they are criticised for a lack of validity and inability to ...