Browsing by Subject "Càncer de pulmó"
Now showing items 1-18 of 18
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Atypical cyclin P regulates cancer cell stemness through activation of the WNT pathway
(Cellular Oncology, 2021)Purpose: Cancer stem cells represent a cancer cell subpopulation that has been found to be associated with metastasis and chemoresistance. Therefore, it is vital to identify mechanisms regulating cancer ... -
CDKN1A/p21 in breast cancer: part of the problem, or part of the solution?
(International Journal of Molecular Sciences, 2023)Cyclin-dependent kinase inhibitor 1A (Cip1/Waf1/CDKN1A/p21) is a well-established protein, primarily recognised for its pivotal role in the cell cycle, where it induces cell cycle arrest by inhibiting ... -
Cpt1c downregulation causes plasma membrane remodelling and anthracycline resistance in breast cancer
(International Journal of Molecular Sciences, 2023)Breast cancer (BC) is the most common malignancy in women worldwide. While the main systemic treatment option is anthracycline-containing chemotherapy, chemoresistance continues to be an obstacle to ... -
Current and future perspectives in lung cancer prevention
(Precision Cancer Medicine, 2020)Smoking is one of the leading causes of morbidity and mortality worldwide. Tobacco smoke contains thousands of different heterogeneous substances, dozens of them classified as carcinogenic for humans, ... -
Estimación del riesgo de cáncer de pulmón en mujeres que participan en un programa de cribado poblacional de cáncer de mama
(Archivos de Bronconeumología, 2020)Introducción: La mortalidad por cáncer de pulmón está aumentando en mujeres. Se ha proyectado que en España pueda superar a la mortalidad por cáncer de mama, la principal causa de mortalidad por cáncer ... -
Estimation of the adult population at high risk of developing lung cancer in the European Union
(Cancer Epidemiology, 2018)Background Lung cancer mortality accounts for over 266,000 deaths in the European Union (EU) every year, most of them attributed to smoking. The aim of this study was to estimate the prevalence of the ... -
Estimation of the population at high risk of developing lung cancer in Chile using simplified eligibility criteria
(Public Health, 2024)Objectives: Several countries in different global regions are implementing lung cancer (LC) screening programmes. This study aimed to estimate the proportion of the Chilean population ≥15 years who are ... -
Expression of oncogenic drivers in 3D cell culture depends on nuclear ATP synthesis by NUDT5
(Cancers, 2019)The growth of cancer cells as oncospheres in three-dimensional (3D) culture provides a robust cell model for understanding cancer progression, as well as for early drug discovery and validation. We have ... -
Health and economic impact at a population level of both primary and secondary preventive lung cancer interventions: A model-based cost-effectiveness analysis
(Lung Cancer, 2021)Objectives: Robust economic evaluations are needed to identify efficient strategies for lung cancer prevention that combine brief and intensive smoking cessation intervention programmes with screening ... -
Present status and future perspectives on the tobacco and nicotine epidemic with a focus on men: a narrative review
(Journal of Men's Health, 2024)Tobacco smoking is one of the main factors of disease burden worldwide. This narrative review presents an overview of this burden, focusing primarily on men. We also discuss the prevention strategies ... -
Prognostic implications of miR-16 expression levels in resected non-small-cell lung cancer
(Journal of Surgical Oncology, 2010-12-29)Background MicroRNAs are novel regulators of gene expression that are linked to the main oncogene networks, including the p53 pathway. p53 regulates the maturation process of miR-16 and miR-143. We ... -
Prospective study of shoulder strength, shoulder range of motion, and lymphedema in breast cancer patients from pre-surgery to 5 years after ALND or SLNB
(Supportive Care in Cancer, 2018)Objective: Determine the changes in shoulder strength, shoulder range of motion, and arm volume in breast cancer patients treated with sentinel lymph node biopsy (SLNB) or axillary lymph node dissection ... -
Role of the NUDT enzymes in breast cancer
(International Journal of Molecular Sciences, 2021)Despite global research efforts, breast cancer remains the leading cause of cancer death in women worldwide. The majority of these deaths are due to metastasis occurring years after the initial treatment ... -
Single Nucleotide Polymorphisms in Tobacco Metabolism and DNA Repair Genes and Prognosis in Resected Non-Small-Cell Lung Cancer
(Journal of Surgical Research, 2011-05-01)Background If tobacco-related carcinogens are not inactivated or extruded from the cell, they can damage the DNA. Single nucleotide polymorphisms (SNPs) in genes involved in tobacco metabolism, DNA ... -
A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer
(2017-08-31)As lung cancer has increased to the most common cause of cancer death worldwide, prognostic biomarkers and efective targeted treatments remain lacking despite advances based on patients’ stratifcation. ... -
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
(Nature Communications, 2018)With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine ... -
Unliganded progesterone receptor governs estrogen receptor gene expression by regulating DNA methylation in breast cancer cells
(Cancers, 2018)Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the estrogen and progesterone receptors (ER and PR, respectively). Although much is known about ERα gene ... -
Unravelling the encapsulation of DNA and other biomolecules in HAp microcalcifications of human breast cancer tissues by raman imaging
(Cancers, 2021)Microcalcifications are detected through mammography screening and, depending on their morphology and distribution (BI-RADS classification), they can be considered one of the first indicators of suspicious ...