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Browsing by Author "Ricco Pacheco, Natalia"

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    • Caracterización molecular de nuevos substratos de la CDK Pho85 

      Ricco Pacheco, Natalia (Date of defense: 2013-07-29)
      La ciclina Cln3 es un activador crítico de START, cuya sobreexpresión provoca células de menor tamaño que progresan rápidamente por el ciclo celular, mientras que su deleción induce un mayor tamaño de ...

    • Comprehensive and quantitative analysis of G1 cyclins. A tool for studying the cell cycle 

      Ballega, Elisabet; Carballar Ruiz, María de los Reyes; Samper Martín, Bàrbara; Ricco Pacheco, Natalia; Ribeiro, Mariana P. C.; Bru Rullo, Samuel; Jiménez, Javier; Clotet Erra, Josep (PLoS One, 2019-06-25)
      In eukaryotes, the cell cycle is driven by the actions of several cyclin dependent kinases (CDKs) and an array of regulatory proteins called cyclins, due to the cyclical expression patterns of the latter. ...

    • Defective in mitotic arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation 

      Hernández-Ortega, Sara; Bru Rullo, Samuel; Ricco Pacheco, Natalia; Ramírez, Sara; Casals i Farré, Núria; Jiménez, Javier; Isasa, Marta; Crosas, Bernat; Clotet Erra, Josep (Journal of Biological Chemistry, 2013-02)
      Progression through the G1 phase of the cell cycle is controlled by diverse cyclin-dependent kinases (CDKs) that might be associated to numerous cyclin isoforms. Given such complexity, regulation of ...

    • Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer 

      Ricco Pacheco, Natalia; Flor, Amy; Wolfgeher, Donald; Efimova, Elena V.; Ramamurthy, Aishwarya; Appelbe, Oliver K.; Brinkman, Jacqueline; Truman, Andrew W.; Spiotto, Michael T.; Kron, Stephen J. (Molecular Oncology, 2019-06-21)
      Radioresistance is a major hurdle in the treatment of head and neck squamous cell carcinoma (HNSCC). Here, we report that concomitant treatment of HNSCCs with radiotherapy and mevalonate pathway inhibitors ...

    • The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage 

      Truman, Andrew W.; Kristjansdottir, Kolbrun; Wolfgeher, Donald; Ricco Pacheco, Natalia; Mayampurath, Anoop; Volchenboum, Samuel L.; Clotet Erra, Josep; Kron, Stephen J. (Data in Brief, 2015-03)
      The molecular chaperones Hsp70 and Hsp90 participate in many important cellular processes, including how cells respond to DNA damage. Here we show the results of applied quantitative affinity-purification ...