• Changes in invasive pneumococcal disease caused by streptococcus pneumoniae serotype 1 following introduction of PCV10 and PCV13: findings from the PSERENADE project 

      Bennett, Julia C.; Hetrich, Marissa K.; Garcia Quesada, Maria; Sinkevitch, Jenna N.; Deloria Knoll, Maria; Feikin, Daniel R.; Zeger, Scott L.; Kagucia, Eunice W.; Cohen, Adam L.; Ampofo, Krow; Brandileone, Maria-Cristina; Bruden, Dana; Camilli, Romina; Castilla, Jesús; Chan, Guanhao; Cook, Heather; Cornick, Jennifer E.; Dagan, Ron; Dalby, Tine; Danis, Kostas; De Miguel, Sara; De Wals, Philippe; Desmet, Stefanie; Georgakopoulou, Theano; Gilkison, Charlotte; Grgic-Vitek, Marta; Hammitt, Laura L.; Hilty, Markus; Ho, Pak-Leung; Jayasinghe, Sanjay; Kellner, James D.; Kleynhans, Jackie; Knol, Mirjam J.; Kozakova, Jana; Kristinsson, Karl G.; Ladhani, Shamez N.; MacDonald, Laura; Mackenzie, Grant A.; Mad’arová, Lucia; McGeer, Allison; Mereckiene, Jolita; Morfeldt, Eva; Mungun, Tuya; Muñoz-Almagro, Carmen; Nuort, J. Pekka; Paragi, Metka; Pilishvili, Tamara; Puentes, Rodrigo; Saha, Samir K.; Sahu Khan, Aalisha; Savrasova, Larisa; Scott, J. Anthony; Skoczynska, Anna; Suga, Shigeru; Van Der Linden, Mark; Verani, Jennifer R.; Von Gottberg, Anne; Winje, Brita A.; Yildirim, Inci; Zerouali, Khalid; Hayford, Kyla; PSERENADE Team (Microorganisms, 2021)
      Streptococcus pneumoniae serotype 1 (ST1) was an important cause of invasive pneumococcal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) containing ST1 antigen. ...
    • Delayed cerebral vasculopathy in pneumococcal meningitis: epidemiology and clinical outcome. A cohort study 

      Boix-Palop, Lucía; Fernández, Tamara; Pelegrín, Iván; Obradors, Meritxell; García-Roulston, Kevin; Xercavins Valls, Mariona; García-Somoza, Dolors; Ardanuy, Carmen; Grau, Javier; Calbo Sebastián, Esther; Cabellos, Carmen (International Journal of Infectious Diseases, 2020-08)
      Background: To describe the prevalence, clinical characteristics, impact of systemic steroids exposure and outcomes of delayed cerebral vasculopathy (DCV) in a cohort of adult patients with pneumococcal ...
    • Impact of the 13-valent conjugated pneumococcal vaccine on the direct costs of invasive pneumococcal disease requiring hospital admission in children aged < 5 years: a prospective study 

      Hernández, Sergi; Navas, Encarna; Aznar-Lou, Ignacio; Ciruela, Pilar; García-García, Juan José; Moraga-Llop, Fernando; Muñoz-Almagro, Carmen; Codina, Gemma; De Sevilla, Mariona F.; González-Peris, Sebastià; Esteva, Cristina; Planes, Ana María; Izquierdo, Conchita; Martínez-Osorio, Johanna; Campins, Magda; Uriona, Sonia; Salleras, Luis; Serrano-Blanco, Antoni; Jané, Mireia; Domínguez, Ángela (Vaccines, 2020)
      The lack of invasive pneumococcal disease (IPD) cost studies may underestimate the eect of pneumococcal polysaccharide conjugated vaccines (PCV). The objective of this study was to estimate the direct ...
    • Nasopharyngeal microbiota in children with invasive pneumococcal disease: identification of bacteria with potential disease-promoting and protective effects 

      Camelo-Castillo, Anny; Henares, Desirée; Brotons, Pedro; Galiana, Antonio; Rodríguez, Juan Carlos; Mira, Alex; Muñoz-Almagro, Carmen; Catalan Study Group of Host- Pathogen Interaction in Patients With IPD (Frontiers in Microbiology, 2019)
      Background and Aims: The risk of suffering from some infectious diseases can be related to specific microbiota profiles. Specifically, the nasopharyngeal microbiota could play a role as a risk or ...
    • Pneumococcal nasopharyngeal carriageamong Bhutanese children hospitalizedwith clinical pneumonia: serotypes andviral co-infection 

      Jullien, Sophie; Sharma, Ragunath; Lhamu Mynak, Mimi; Henares, Desirée; Muñoz-Almagro, Carmen; Bassat, Quique (BMC Infectious Diseases, 2020-12)
      Background: Pneumococcal nasopharyngeal colonization (PNC) generally precedes pneumococcal disease. The purpose of this study was to determine the prevalence of PNC and to identify the pneumococcal ...
    • Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era 

      Izquierdo, Conchita; Ciruela, Pilar; Hernández, Sergi; García-García, Juan José; Esteva, Cristina; Moraga-Llop, Fernando; Díaz-Conradi, A.; Martínez-Osorio, Johanna; Solé-Ribalta, Anna; De Sevilla, Mariona F.; González-Peris, Sebastià; Codina, Gemma; Planes, Ana María; Uriona, Sonia; Campins, Magda; Muñoz-Almagro, Carmen; Salleras, Luis; Domínguez, Ángela (Epidemiology and Infection, 2020-11)
      The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study ...
    • Rapid identification, capsular typing and molecular characterization of streptococcus pneumoniae by using whole genome nanopore sequencing 

      Garcia-Garcia, Selene; Perez-Arguello, A.; Henares, Desirée; Timoneda, N.; Muñoz-Almagro, Carmen (BMC Microbiology, 2020)
      Background: Whole genome sequencing has emerged as a useful tool for identification and molecular characterization of pathogens. MinION (Oxford Nanopore) is a real-time third generation sequencer whose ...
    • Related factors to streptococcus pneumoniae invasive infection and clinical manifestations: the potential role of nasopharyngeal microbiome 

      Dietl, Beatriz; Henares, Desirée; Boix-Palop, Lucía; Muñoz-Almagro, Carmen; Garau, Javier; Calbo Sebastián, Esther (Frontiers in Medicine, 2021-04)
      Infections of the lower respiratory tract, such as pneumonia, are one of the leading causes of death worldwide. Streptococcus pneumoniae might colonize the upper respiratory tract and is the main ...
    • Serotype and clonal distribution dynamics of invasive pneumococcal strains after PCV13 introduction (2011-2016): surveillance data from 23 sites in Catalonia, Spain 

      Ludwig, Guillermo; Garcia-Garcia, Selene; Lanaspa, Miguel; Ciruela, Pilar; Esteva, Cristina; Fernandez de Sevilla, Mariona; Diaz-Conradi, Alvaro; Marti, Carmina; Motje, Montse; Galles, Carme; Morta, Montse; Izquierdo, Conchita; Moraga-Llop, Fernando; Campins, Magda; Salleras, Luis; Jané, Mireia; Domínguez, Ángela; Garcia-Garcia, Juan Jose; Muñoz-Almagro, Carmen; Catalan Study Group of Invasive Pneumococcal Disease (PLoS One, 2020-02)
      Background: The objective of this study is to describe incidence and shifts of serotype and clonal distribution of invasive Streptococcus pneumoniae strains in four different age groups (<5 years, 5–17 ...
    • Serotype distribution of remaining pneumococcal meningitis in the mature PCV10/13 period: findings from the PSERENADE project 

      Garcia Quesada, Maria; Yang, Yangyupei; Bennett, Julia C.; Hayford, Kyla; Zeger, Scott L.; Feikin, Daniel R.; Peterson, Meagan E.; Cohen, Adam L.; Almeida, Samanta C. G.; Ampofo, Krow; Ang, Michelle; Bar-Zeev, Naor; Bruce, Michael G.; Camilli, Romina; Chanto Chacón, Grettel; Ciruela, Pilar; Cohen, Cheryl; Corcoran, Mary; Dagan, Ron; De Wals, Philippe; Desmet, Stefanie; Diawara, Idrissa; Gierke, Ryan; Guevara, Marcela; Hammitt, Laura L.; Hilty, Markus; Ho, Pak-Leung; Jayasinghe, Sanjay; Kleynhans, Jackie; Kristinsson, Karl G.; Ladhani, Shamez N.; McGeer, Allison; Mwenda, Jason M.; Nuort, J. Pekka; Oishi, Kazunori; Ricketson, Leah J.; Sanz, Juan Carlos; Savrasova, Larisa; Setchanova, Lena Petrova; Smith, Andrew; Valentiner-Branth, Palle; Valenzuela, Maria Teresa; Van der Linden, Mark; Van Sorge, Nina M.; Varon, Emmanuelle; Winje, Brita A.; Yildirim, Inci; Zintgraff, Jonathan; Knoll, Maria Deloria; PSERENADE Team (Microorganisms, 2021)
      Pneumococcal conjugate vaccine (PCV) introduction has reduced pneumococcal meningitis incidence. The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project described the ...
    • Validation of a loop-mediated isothermal amplification assay for rapid diagnosis of invasive pneumococcal disease 

      De Paz, Héctor David; Brotons, Pedro; Esteva, Cristina; Muñoz-Almagro, Carmen (Frontiers in Cellular and Infection Microbiology, 2020-03-24)
      Current molecular PCR-based techniques used for detecting Streptococcus pneumoniae, the causative pathogen of invasive pneumococcal disease (IPD), are accurate but have a run time of several hours. We ...