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Listando por materia "Neurociencias"

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    • CPT1C and endocannabinoids as hypothalamic players in early stages of obesity development 

      Miralpeix Monclús, Cristina (Fecha de defensa: 2019-12-10)
      Obesity prevalence in worldwide population is increasing every day due to an imbalance between the energy intake and the energy expenditure. Rich-caloric food is highly palatable and easily accessible, ...

    • CPT1C-dependent regulation of GluA1 trafficking under metabolic stress 

      Casas Prat, María (Fecha de defensa: 2019-12-10)
      Carnitine palmitoyltransferase 1C (CPT1C) is the brain-specific isoform of the CPT1 family which is located at the endoplasmic reticulum (ER) of neurons and exhibits low catalytic activity, but still ...

    • El médico como segunda víctima en los casos de reclamación profesional por malapraxis 

      Vizcaíno Rakosnik, Marta (Fecha de defensa: 2021-06-15)
      La primera y principal víctima de un evento adverso en la asistencia es el paciente y su entorno, sin embargo, la psicología reconoce el sufrimiento de la segunda víctima. Si dicho evento adverso se ...

    • Mechanisms of CPT1C-Dependent AMPAR trafficking enhancement 

      Gratacòs-Batlle, Esther; Olivella, Mireia; Sánchez-Fernández, Nuria; Yefimenko, Natalia; MIguez-Cabello, Federico; Fadó Andrés, Rut; Casals i Farré, Núria; Gasull, Xavier; Ambrosio, Santiago; Soto, David (Frontiers in Molecular Neuroscience, 2018-08-08)
      In neurons, AMPA receptor (AMPAR) function depends essentially on their constituent components: the ion channel forming subunits and ion channel associated proteins. On the other hand, AMPAR trafficking ...

    • Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking 

      Casas, Maria; Fadó Andrés, Rut; Domínguez, José Luis; Roig, Aina; Kaku, Moena; Chohnan, Shigeru; Solé, Montse; Unzeta, Mercedes; Miñano Molina, Alfredo Jesús; Rodríguez-Álvarez, José; Dickson, Eamonn James; Casals i Farré, Núria (Journal of Cell Biology, 2020)
      Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ...

    • Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking 

      Casas, Maria; Rut, Fadó; Domínguez, José Luis; Roig, Aina; Kaku, Moena; Chohnan, Shigeru; Solé, Montse; Unzeta, Mercedes; Miñano Molina, Alfredo Jesús; Rodríguez-Álvarez, José; James Dickson, Eamonn; Casals i Farré, Núria (Journal of Cell Biology, 2020-09)
      Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ...

    • Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth 

      Palomo Guerrero, Marta; Fadó Andrés, Rut; Casas, Maria; Pérez-Montero, Marta; Baena, Miguel; Helmer, Patrick O.; Domínguez, José Luis; Roig, Aina; Serra, Dolors; Hayen, Heiko; Stenmark, Harald; Raiborg, Camilla; Casals i Farré, Núria (eLife, 2019)
      Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty ...

    • X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk 

      Fadó Andrés, Rut; Moubarak, Rana S.; Miñano Molina, Alfredo Jesús; Barneda-Zahonero, Bruna; Valero, Jorge; Saura, Carlos A.; Moran, Julio; Comella, Joan X.; Rodríguez-Álvarez, José (Scientific Reports, 2013-08-09)
      X-linked Inhibitor of apoptosis protein (XIAP) has been classically identified as a cell death regulator. Here, we demonstrate a novel function of XIAP as a regulator of neurite outgrowth in neuronal ...