Browsing by Subject "Cicle cel·lular"
Now showing items 1-9 of 9
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Atypical cyclins: the extended family portrait
(Cellular and Molecular Life Sciences, 2020)Regulation of cell division is orchestrated by cyclins, which bind and activate their catalytic workmates, the cyclin-dependent kinases (CDKs). Cyclins have been traditionally defined by an oscillating ... -
CDKN1A/p21 in breast cancer: part of the problem, or part of the solution?
(International Journal of Molecular Sciences, 2023)Cyclin-dependent kinase inhibitor 1A (Cip1/Waf1/CDKN1A/p21) is a well-established protein, primarily recognised for its pivotal role in the cell cycle, where it induces cell cycle arrest by inhibiting ... -
Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress
(Life Science Alliance, 2019-04-15)The precise coordination of growth and proliferation has a universal prevalence in cell homeostasis. As a prominent property, cell size is modulated by the coordination between these processes in ... -
El polifosfat és un element clau durant la replicació del DNA.
(Date of defense: 2015-11-06)Throughout its lifespan, eukaryotic cells steadily consume free cytoplasmic orthophosphate to produce phospholipids and mRNA. However, during DNA synthesis, in a matter of minutes, cells require large ... -
Estudi de la ciclina atípica CCNI com a potencial activador de CDK6 en línies de càncer de mama
(Date of defense: 2022-02-09)Fa quasi 40 anys del descobriment de les ciclines, les proteïnes oscil·lants tradicionalment dividies en dos grups, “cicle cel·lular” i “ciclines transcripcionals”, que duen a terme els seus rols juntament ... -
Growth rate as a direct regulator of the start network to set cell size
(Frontiers in Cell and Developmental Biology, 2017-05-26)Cells are able to adjust their growth and size to external inputs to comply with specific fates and developmental programs. Molecular pathways controlling growth also have an enormous impact in cell ... -
Iron Regulation and the Cell Cycle: identification of an iron-responsive element in the 3′-untranslated region of human cell division cycle 14a mrna by a refined microarray-based screening strategy
(The Journal of Biological Chemistry, 2006)Iron regulatory proteins (IRPs) 1 and 2 post-transcriptionally control mammalian iron homeostasis by binding to iron-responsive elements (IREs), conserved RNA stem-loop structures located in the 5′- or ... -
Regulación del ciclo celular por ploidía en Saccharomyces cerevisiae
(Date of defense: 2018-02-02)Una de les característiques cel·lulars amb més impacte sobre la seva fisiologia cel·lular és la mida, regulada per multitud de factors extrínsecs i intrínsecs, i una característica de vital rellevància ... -
Signalling network of breast cancer cells in response to progesterone
(BioRxiv, 2020)Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that transmit ...