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    • CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst 

      Zagmutt, Sebastián; Mera, Paula; González-García, Ismael; Ibeas, Kevin; Romero, María del Mar; Obri, Arnaud; Martin, Beatriz; Esteve-Codina, Anna; Soler Vázquez, M. Carmen; Bastías Pérez, Marianela Pía ; Cañes, Laia; Augé, Elisabeth; Pelegri, Carme; Vilaplana, Jordi; Ariza, Xavier; García, Jordi; Martinez González, José; Casals, Núria; López, Miguel; Palmiter, Richard; Sanz, Elisenda; Quintana, Albert; Herrero, Laura; Serra, Dolors (Biology of Sex Differences, 2023)
      Background: Fatty acid metabolism in the hypothalamus has an important role in food intake, but its specific role in AgRP neurons is poorly understood. Here, we examined whether carnitinea palmitoyltransferase ...

    • CPT1C deficiency in SF1 neurons impairs early metabolic adaptation to dietary fats, leading to obesity 

      Fosch, Anna; Sánchez Pizarro, David; Zagmutt, Sebastian; Reguera, Ana Cristina; Batallé, Gerard; Rodríguez-García, Maria; García-Chica, Jesus; Freire-Agulleiro, Oscar; Miralpeix, Cristina; Zizzari, Philippe; Serra, Dolors; Herrero, Laura; López, Miguel; Cota, Daniela; Rodríguez Rodríguez, Rosalía; Casals, Núria (Molecular Metabolism, 2025)
      Objectives: SF1 neurons of the ventromedial hypothalamus (VMH) play a pivotal role in regulating body weight and adiposity, particularly in response to a high-fat diet (HFD), as well as in the recovery ...