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Antiretroviral therapy suppressed participants withlow CD4RT-cell counts segregate according toopposite immunological phenotypes
(AIDS, 2016-09)Background:The failure to increase CD4þT-cell counts in some antiretroviral therapysuppressed participants (immunodiscordance) has been related to perturbed CD4þT-cell homeostasis and impacts clinical ... -
SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2
(Cell Communication and Signaling18;147, 2020-09-10)Background: Deficiency of mitochondrial sirtuin 3 (SIRT3), a NAD+-dependent protein deacetylase that maintains redox status and lipid homeostasis, contributes to hepatic steatosis. In this study, we ... -
The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation
(Nature Communications, 2012-08-21)Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size ...