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    • The ADP-ribose hydrolase NUDT5 is important for DNA repair 

      Qi, Hongyun; Wright, Roni; Beato, Miguel; Price, Brendan (Cell Reports, 2022-12)
      DNA damage leads to rapid synthesis of poly(ADP-ribose) (pADPr), which is important for damage signaling and repair. pADPr chains are removed by poly(ADP-ribose) glycohydrolase (PARG), releasing free ...

    • Global signalling network analysis of luminal T47D breast cancer cells in response to progesterone 

      Wright, Roni; Vastolo, Viviana; Quilez, Javier; Carbonell Caballero, José; Beato, Miguel (Frontiers in Endocrinology, 2022)
      Background: Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that ...