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Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status
(British Journal of Pharmacology, 2021-01)Background and Purpose: The enzyme α/β‐hydrolase domain containing 6 (ABHD6), a new member of the endocannabinoid system, is a promising therapeutic target against neuronal‐related diseases. However, ... -
Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol
(Journal of Lipid Research, 2012)A novel lyase activity enzyme is characterized for the first time: HMG-CoA lyase-like1 (er-cHL), which is a close homolog of mitochondrial HMG-CoA lyase (mHL). Initial data show that there are nine ... -
CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity
(Journal of Biological Chemistry, 2008)CPT1c is a carnitine palmitoyltransferase 1 (CPT1) isoform that is expressed only in the brain. The enzyme has recently been localized in neuron mitochondria. Although it has high sequence identity with ... -
Editorial for “Psychophysical Evaluation of Visual vs. Computer Aided Detection of Brain Lesions on Magnetic Resonance Images”
(Journal of Magnetic Resonance Imaging, 2022) -
Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12
(Cell Death and Disease, 2011-04-28)Disturbance of calcium homeostasis and accumulation of misfolded proteins in the endoplasmic reticulum (ER) are considered contributory components of cell death after ischemia. However, the signal-transducing ... -
Oscillation encoding of individual differences in speech perception
(PLoS One, 2014-07-03)Individual differences in second language (L2) phoneme perception (within the normal population) have been related to speech perception abilities, also observed in the native language, in studies assessing ... -
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking
(Journal of Cell Biology, 2020-09)Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ... -
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking
(Journal of Cell Biology, 2020)Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ... -
The return of malonyl-CoA to the brain: cognition and other stories
(Progress in Lipid Research, 2021-01)Nutrients, hormones and the energy sensor AMP-activated protein kinase (AMPK) tightly regulate the intracel-lular levels of the metabolic intermediary malonyl-CoA, which is a precursor of fatty ...