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    • Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status 

      Miralpeix Monclús, Cristina; Reguera, Ana Cristina; Fosch, Anna; Casas, Maria; Lillo, Jaume; Navarro, Gemma; Franco, Rafael; Casas, Josefina; Alexander, Stephen P.H.; Casals i Farré, Núria; Rodríguez-Rodríguez, Rosalía (British Journal of Pharmacology, 2021-01)
      Background and Purpose: The enzyme α/β‐hydrolase domain containing 6 (ABHD6), a new member of the endocannabinoid system, is a promising therapeutic target against neuronal‐related diseases. However, ...

    • Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol 

      Arnedo, María; Menao, Sebastián; Puisac, Beatriz; Teresa-Rodrigo, María E.; Gil-Rodríguez, María C.; López-Viñas, Eduardo; Gómez-Puertas, Paulino; Casals i Farré, Núria; Casale, César H.; Hegardt, Fausto G.; Pié, Juan (Journal of Lipid Research, 2012)
      A novel lyase activity enzyme is characterized for the first time: HMG-CoA lyase-like1 (er-cHL), which is a close homolog of mitochondrial HMG-CoA lyase (mHL). Initial data show that there are nine ...

    • CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity 

      Sierra, Adriana Y.; Gratacòs-Batlle, Esther; Carrasco, Patricia; Clotet Erra, Josep; Ureña, Jesús; Serra, Dolors; Asins, Guillermina; Hegardt, Fausto G.; Casals i Farré, Núria (Journal of Biological Chemistry, 2008)
      CPT1c is a carnitine palmitoyltransferase 1 (CPT1) isoform that is expressed only in the brain. The enzyme has recently been localized in neuron mitochondria. Although it has high sequence identity with ...

    • Editorial for “Psychophysical Evaluation of Visual vs. Computer Aided Detection of Brain Lesions on Magnetic Resonance Images” 

      Puyalto, Paloma (Journal of Magnetic Resonance Imaging, 2022)

    • Genomic and serologic characterization ofenterovirus A71 brainstem encephalitis 

      Leon, Kristoffer E.; Schubert, Ryan D.; Casas-Alba, Didac; Hawes, Isobel A.; Ramachandran, Prashanth S.; Ramesh, Akshaya; Pak, John E.; Wu, Wesley; Cheung, Carly K.; Crawford, Emily D.; Khan, Lillian M.; Launes, Cristian; Sample, Hannah A.; Zorn, Kelsey C.; Cabrerizo, María; Valero-Rello, Ana; Langelier, Charles; Muñoz-Almagro, Carmen; DeRisi, Joseph L.; Wilson, Michael R. (Neurology: Neuroimmunology & Neuroinflammation, 2020)
      Objective: In 2016, Catalonia experienced a pediatric brainstem encephalitis outbreak caused by enterovirus A71 (EV-A71). Conventional testing identified EV in the periphery but rarely in CSF. Metagenomic ...

    • Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12 

      Badiola, Nahuai; Penas, Clara; Miñano Molina, Alfredo Jesús; Barneda-Zahonero, Bruna; Fadó Andrés, Rut; Sánchez-Opazo, G.; Comella, Joan X.; Sabrià, Josefa; Zhu, Chuanshuai; Blomgren, Klas; Casas, Caty; Rodríguez-Álvarez, José (Cell Death and Disease, 2011-04-28)
      Disturbance of calcium homeostasis and accumulation of misfolded proteins in the endoplasmic reticulum (ER) are considered contributory components of cell death after ischemia. However, the signal-transducing ...

    • Oscillation encoding of individual differences in speech perception 

      Jin, Yu; Díaz Menéndez, Begoña; Colomer, Marc; Sebastián-Gallés, Núria (PLoS One, 2014-07-03)
      Individual differences in second language (L2) phoneme perception (within the normal population) have been related to speech perception abilities, also observed in the native language, in studies assessing ...

    • Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking 

      Casas, Maria; Fadó Andrés, Rut; Domínguez, José Luis; Roig, Aina; Kaku, Moena; Chohnan, Shigeru; Solé, Montse; Unzeta, Mercedes; Miñano Molina, Alfredo Jesús; Rodríguez-Álvarez, José; Dickson, Eamonn James; Casals i Farré, Núria (Journal of Cell Biology, 2020)
      Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ...

    • Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking 

      Casas, Maria; Rut, Fadó; Domínguez, José Luis; Roig, Aina; Kaku, Moena; Chohnan, Shigeru; Solé, Montse; Unzeta, Mercedes; Miñano Molina, Alfredo Jesús; Rodríguez-Álvarez, José; James Dickson, Eamonn; Casals i Farré, Núria (Journal of Cell Biology, 2020-09)
      Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ...

    • The return of malonyl-CoA to the brain: cognition and other stories 

      Fadó Andrés, Rut; Rodríguez-Rodríguez, Rosalía; Casals i Farré, Núria (Progress in Lipid Research, 2021-01)
      Nutrients, hormones and the energy sensor AMP-activated protein kinase (AMPK) tightly regulate the intracel-lular levels of the metabolic intermediary malonyl-CoA, which is a precursor of fatty ...