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Novel mutations in the ferritin-L iron-responsive element that only mildly impair IRP binding cause hereditary hyperferritinaemia cataract syndrome

Luscieti, Sara; Tolle, Gabriele; Aranda, Jessica; Benet Campos, Carmen; Risse, Frank; Morán, Érica; Muckenthaler, Martina U.; Sánchez, Mayka (Orphanet Journal of Rare Diseases, 2013)

Background: Hereditary Hyperferritinaemia Cataract Syndrome (HHCS) is a rare autosomal dominant disease characterized by increased serum ferritin levels and early onset of bilateral cataract. The disease ...

Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologies

Bonilla-Vidal, L.; Espina, M.; García, M.L.; Baldomà, L.; Badia, J.; González, J.A.; Delgado, L.M.; Gliszczyńska, A.; Souto, E.B.; Sánchez-López, E. (International Journal of Pharmaceutics, 2024)

Dry eye disease (DED) is a chronic multifactorial disorder of the ocular surface caused by tear film dysfunction and constitutes one of the most common ocular conditions worldwide. However, its treatment ...

Novel regulation of the synthesis of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit gluA1 by carnitine palmitoyltransferase 1C (CPT1C) in the hippocampus

Fadó Andrés, Rut; Soto, David; Miñano Molina, Alfredo Jesús; Pozo Ariza, Macarena; Carrasco, Patricia; Yefimenko, Natalia; Rodríguez-Álvarez, José; Casals i Farré, Núria (Journal of Biological Chemistry, 2015-10-16)

The regulation of AMPA-type receptor (AMPAR) abundance in the postsynaptic membrane is an important mechanism involved in learning and memory formation. Recent data suggest that one of the constituents ...

Novel strategies enhancing endodontic disinfection: antibacterial biodegradable calcium hydroxide nanoparticles in an ex vivo model

Elmsmari, Firas; Delgado, Luis María; Duran-Sindreu, Fernando; A. Pérez, Román; García, Maria Luisa; Teulé Trull, Míriam; Afrashtehfar, Kelvin I.; González, José Antonio; Sánchez-López, Elena (International Journal of Pharmaceutics, 2023)

Due to the high failure rates associated to endodontic disinfection, this study aimed to investigate the antibacterial properties of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with ...