Listando por autor/a "Fadó Andrés, Rut"
Mostrando ítems 1-18 de 18
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Bone morphogenetic protein-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway
Barneda-Zahonero, Bruna; Miñano Molina, Alfredo Jesús; Badiola, Nahuai; Fadó Andrés, Rut; Xifró Collsamata, Xavier; Saura, Carlos A.; Rodríguez Álvarez, José (2009-12-15)Bone morphogenetic proteins (BMPs) have been implicated in the generation and postnatal differentiation of cerebellar granule cells (CGCs). Here, we examined the eventual role of BMPs on the survival ... -
CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy
Roa Mansergas, Xavier; Fadó Andrés, Rut; Atari Abouassi, Maher; Mir, Joan Francesc; Muley Vilamú, Helena; Serra, Dolors; Casals i Farré, Núria (Scientific Reports, 2018-05-03)Human mesenchymal stem cells (hMSCs) are widely used in regenerative medicine. In some applications, they must survive under low nutrient conditions engendered by avascularity. Strategies to improve ... -
CPT1C-dependent regulation of GluA1 trafficking under metabolic stress
Casas Prat, María (Fecha de defensa: 2019-12-10)Carnitine palmitoyltransferase 1C (CPT1C) is the brain-specific isoform of the CPT1 family which is located at the endoplasmic reticulum (ER) of neurons and exhibits low catalytic activity, but still ... -
Feeding the brain: effect of nutrients on cognition, synaptic function, and AMPA receptors
Fadó Andrés, Rut; Molins , Anna; Rojas Martín, Rocío; Casals, Nuria (Nutrients, 2022)In recent decades, traditional eating habits have been replaced by a more globalized diet, rich in saturated fatty acids and simple sugars. Extensive evidence shows that these dietary factors contribute ... -
Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12
Badiola, Nahuai; Penas, Clara; Miñano Molina, Alfredo Jesús; Barneda-Zahonero, Bruna; Fadó Andrés, Rut; Sánchez-Opazo, G.; Comella, Joan X.; Sabrià, Josefa; Zhu, Chuanshuai; Blomgren, Klas; Casas, Caty; Rodríguez-Álvarez, José (Cell Death and Disease, 2011-04-28)Disturbance of calcium homeostasis and accumulation of misfolded proteins in the endoplasmic reticulum (ER) are considered contributory components of cell death after ischemia. However, the signal-transducing ... -
Mechanisms of CPT1C-Dependent AMPAR trafficking enhancement
Gratacòs-Batlle, Esther; Olivella, Mireia; Sánchez-Fernández, Nuria; Yefimenko, Natalia; MIguez-Cabello, Federico; Fadó Andrés, Rut; Casals i Farré, Núria; Gasull, Xavier; Ambrosio, Santiago; Soto, David (Frontiers in Molecular Neuroscience, 2018-08-08)In neurons, AMPA receptor (AMPAR) function depends essentially on their constituent components: the ion channel forming subunits and ion channel associated proteins. On the other hand, AMPAR trafficking ... -
N-methyl-DD-aspartate blocks activation of JNK and mitochondrial apoptotic pathway induced by potassium deprivation in cerebellar granule cells
Xifró Collsamata, Xavier; Falluel-Morel, Anthony; Miñano Molina, Alfredo Jesús; Aubert, Nicolas; Fadó Andrés, Rut; Malagelada, Cristina; Vaudry, David; Vaudry, Hubert; Gonzalez, Druno; Rodríguez-Álvarez, José (Journal of Biological Chemistry, 2006-03-10)During the postnatal development of cerebellum, lack of excitatory innervation from the mossy fibers results in cerebellar granule cell (CGC) apoptosis during the migration of the cells toward the ... -
Novel regulation of the synthesis of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit gluA1 by carnitine palmitoyltransferase 1C (CPT1C) in the hippocampus
Fadó Andrés, Rut; Soto, David; Miñano Molina, Alfredo Jesús; Pozo Ariza, Macarena; Carrasco, Patricia; Yefimenko, Natalia; Rodríguez-Álvarez, José; Casals i Farré, Núria (Journal of Biological Chemistry, 2015-10-16)The regulation of AMPA-type receptor (AMPAR) abundance in the postsynaptic membrane is an important mechanism involved in learning and memory formation. Recent data suggest that one of the constituents ... -
Nurr1 protein Is required for N-methyl-d-aspartic acid (NMDA) receptor-mediated neuronal survival
Barneda-Zahonero, Bruna; Servitja, Joan-Marc; Badiola, Nahuai; Miñano Molina, Alfredo Jesús; Fadó Andrés, Rut; Saura, Carlos A.; Rodríguez-Álvarez, José (Journal of Biological Chemistry, 2012-03-30)NMDA receptor (NMDAR) stimulation promotes neuronal survival during brain development. Cerebellar granule cells (CGCs) need NMDAR stimulation to survive and develop. These neurons differentiate and ... -
Proteasomal-mediated degradation of AKAP150 accompanies AMPAR endocytosis during cLTD
Cheng, Wenwen; Siedlecki-Wullich, Dolores; Català-Solsona, Judit; Fábregas, Cristina; Fadó Andrés, Rut; Casals i Farré, Núria; Solé, Montse; Unzeta, Mercedes; Saura, Carlos A.; Rodríguez-Álvarez, José; Miñano Molina, Alfredo Jesús (eNeuro, 2020-03-23)The number and function of synaptic AMPA receptors (AMPARs) tightly regulates excitatory synaptic transmission. Current evidence suggests that AMPARs are inserted into the postsynaptic membrane during ... -
Rol de CPT1C en la supervivencia de las células madre mesenquimales
Roa Mansergas, Xavier (Fecha de defensa: 2016-09-06)La carnitina palmitoiltransferasa 1C (CPT1C) pertenece a la familia de enzimas CPT1, las cuales controlan la entrada de ácidos grasos al lumen de la mitocondria para su posterior oxidación. Sin embargo, ... -
Role of CPT1C in breast cancer development and chemoresistance
Muley Vilamú, Helena (Fecha de defensa: 2021-07-14)Carnitine palmitoyl transferase 1 (CPT1) are enzymes that catalyze the conversion of long-chain acyl-CoA to acyl-carnitines, to transport long-chain fatty acids across intracellular membranes. CPT1C ... -
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking
Casas, Maria; Fadó Andrés, Rut; Domínguez, José Luis; Roig, Aina; Kaku, Moena; Chohnan, Shigeru; Solé, Montse; Unzeta, Mercedes; Miñano Molina, Alfredo Jesús; Rodríguez-Álvarez, José; Dickson, Eamonn James; Casals i Farré, Núria (Journal of Cell Biology, 2020)Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key ... -
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
Palomo Guerrero, Marta; Fadó Andrés, Rut; Casas, Maria; Pérez-Montero, Marta; Baena, Miguel; Helmer, Patrick O.; Domínguez, José Luis; Roig, Aina; Serra, Dolors; Hayen, Heiko; Stenmark, Harald; Raiborg, Camilla; Casals i Farré, Núria (eLife, 2019)Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty ... -
Soluble oligomers of amyloid-β peptide disrupt Membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction
Miñano Molina, Alfredo Jesús; España, Judit; Martín, Elsa; Barneda-Zahonero, Bruna; Fadó Andrés, Rut; Solé, Montse; Trullás, Ramón; Saura, Carlos A.; Rodríguez-Álvarez, José (Journal of Biological Chemistry, 2011-08-05)β-Amyloid (Aβ), a peptide generated from the amyloid precursor protein, is widely believed to underlie the pathophysiology of Alzheimer disease (AD). Emerging evidences suggest that soluble Aβ oligomers ... -
The return of malonyl-CoA to the brain: cognition and other stories
Fadó Andrés, Rut; Rodríguez-Rodríguez, Rosalía; Casals i Farré, Núria (Progress in Lipid Research, 2021-01)Nutrients, hormones and the energy sensor AMP-activated protein kinase (AMPK) tightly regulate the intracel-lular levels of the metabolic intermediary malonyl-CoA, which is a precursor of fatty ... -
To be or not to be a fat burner, that is the question for cpt1c in cancer cells
Fadó Andrés, Rut; Zagmutt, Sebastián; Herrero, Laura; Muley, Helena; Rodriguez-Rodriguez, Rosalia; Bi, Huichang; Serra, Dolors; Casals, Nuria (Cell Death & Disease, 2023)There is an urgent need to identify reliable genetic biomarkers for accurate diagnosis, prognosis, and treatment of different tumor types. Described as a prognostic marker for many tumors is the neuronal ... -
X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk
Fadó Andrés, Rut; Moubarak, Rana S.; Miñano Molina, Alfredo Jesús; Barneda-Zahonero, Bruna; Valero, Jorge; Saura, Carlos A.; Moran, Julio; Comella, Joan X.; Rodríguez-Álvarez, José (Scientific Reports, 2013-08-09)X-linked Inhibitor of apoptosis protein (XIAP) has been classically identified as a cell death regulator. Here, we demonstrate a novel function of XIAP as a regulator of neurite outgrowth in neuronal ...