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Hypothalamic Ceramide Levels regulated by CPT1C mediate the Orexigenic effect of Ghrelin
(Universitat Internacional de Catalunya, 2014-07-31)
Recent data suggest that ghrelin exerts its orexigenic action through regulation of hypothalamic AMP-activated protein kinase pathway, leading to a decline in malonyl-CoA levels and desinhibition of ...
CPT1c in specific hypothalamic nuclei and its role in lipid sensing and metabolic adaptation
(Universitat Internacional de Catalunya, 2022-09-23)
Obesity has become a pandemic disease in the last 40 years. The WHO estimates that the
population with overweight has nearly tripled since 1975, and the tendency is still growing.
These data have an ...
Papel de CPT1C en el control de la Homeostasis Energética
(Universitat Internacional de Catalunya, 2015-09-10)
En los últimos años se ha tratado de profundizar en el estudio de los mecanismos moleculares a nivel hipotalámico responsables de regular el balance energético.
En la actualidad se conoce que el ...
Extracellular UTP signalling in Schwann cell migration: A novel role of the P2Y2 receptor
(Universitat Internacional de Catalunya, 2013-09-24)
Peripheral neuropaties are one of the major complications of the Peripheral Nervous System. Depsite the big importance of those pathologies, less drugs are effective for their treatment, and most of the ...
Paper de la Proteïna CPT1C en la Síntesis de Ceramides i en la Funció Motora
(Universitat Internacional de Catalunya, 2015-05-14)
La β-oxidació dels àcids grassos al mitocondri és una de les principals fonts per a l’obtenció d’energia per a les cèl·lules. Per a que ocorri, cal que els àcids grassos siguin transportats a la matriu ...
Rol de CPT1C en la supervivencia de las células madre mesenquimales
(Universitat Internacional de Catalunya, 2016-09-06)
La carnitina palmitoiltransferasa 1C (CPT1C) pertenece a la familia de enzimas CPT1, las cuales controlan la entrada de ácidos grasos al lumen de la mitocondria para su posterior oxidación. Sin embargo, ...
CPT1C and endocannabinoids as hypothalamic players in early stages of obesity development
(Universitat Internacional de Catalunya, 2019-12-10)
Obesity prevalence in worldwide population is increasing every day due to an imbalance between the energy intake and the energy expenditure. Rich-caloric food is highly palatable and easily accessible, ...
CPT1C-dependent regulation of GluA1 trafficking under metabolic stress
(Universitat Internacional de Catalunya, 2019-12-10)
Carnitine palmitoyltransferase 1C (CPT1C) is the brain-specific isoform of the CPT1 family which is located at the endoplasmic reticulum (ER) of neurons and exhibits low catalytic activity, but still ...
Papel de CPT1C en el desarrollo axonal y en el transporte de los endosomas tardíos
(Universitat Internacional de Catalunya, 2018-03-23)
La paraplejía espástica hereditaria agrupa un conjunto de desórdenes neurodegenerativos caracterizados por espasticidad y rigidez muscular. Todos ellos están relacionados clínica y patológicamente con ...
Role of CPT1C in breast cancer development and chemoresistance
(Universitat Internacional de Catalunya, 2021-07-14)
Carnitine palmitoyl transferase 1 (CPT1) are enzymes that catalyze the conversion of long-chain acyl-CoA to acyl-carnitines, to transport long-chain fatty acids across intracellular membranes. CPT1C ...