Single-molecule stochastic resonance
Autor/a
Hayashi, K.
de Lorenzo, S.
Manosas, M.
Huguet Casades, Josep Maria
Ritort, F.
Data de publicació
2012ISSN
2160-3308
Resum
Stochastic resonance (SR) is a well-known phenomenon in dynamical systems. It consists of the amplification and optimization of the response of a system assisted by stochastic (random or probabilistic) noise. Here we carry out the first experimental study of SR in single DNA hairpins which exhibit cooperatively transitions from folded to unfolded configurations under the action of an oscillating mechanical force applied with optical tweezers. By varying the frequency of the force oscillation, we investigate the folding and unfolding kinetics of DNA hairpins in a periodically driven bistable free-energy potential. We measure several SR quantifiers under varied conditions of the experimental setup such as trap stiffness and length of the molecular handles used for single-molecule manipulation. We find that a good quantifier of the SR is the signal-to-noise ratio (SNR) of the spectral density of measured fluctuations in molecular extension of the DNA hairpins. The frequency dependence of the SNR exhibits a peak at a frequency value given by the resonance-matching condition. Finally, we carry out experiments on short hairpins that show how SR might be useful for enhancing the detection of conformational molecular transitions of low SNR.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
61 - Medicina
Paraules clau
Física biològica
Dinàmica no lineal
Física estadística
Física biológica
Dinámica no lineal
Física estadística
Biological Physics
Nonlinear Dynamics
Statistical Physics
Pàgines
11
Publicat per
American Physical Society
Col·lecció
2
Publicat a
Physical Review X
Citació
Hayashi, K.; de Lorenzo, S.; Manosas, M. [et al.]. Single-molecule stochastic resonance. Physical Review X, 2012, 2, 031012 . Disponible en: <https://journals.aps.org/prx/abstract/10.1103/PhysRevX.2.031012>. Fecha de acceso: 18 mar. 2024. DOI: 10.1103/PhysRevX.2.031012.
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Drets
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