Feasibility of umbilical cord blood as a source of red blood cell transfusion in preterm infants blood transfusion
Autor/a
García González, Elsa
Alsina Casanova, Miguel
Samarkanova, Dinara
Palacio, Marta Teresa
Farssac Busquets, Elisenda
Figueras-Aloy, Josep
Salvia-Roigés, Mª Dolors
Querol, Sergi
Fecha de publicación
2021ISSN
2385-2070
Resumen
Background - Preterm infants born earlier than 32 weeks of gestational age (GA) often need red blood cell (RBC) transfusions, which have been associated with an increased incidence of complications of prematurity, due to changes in tissue oxygenation. Transfusion of umbilical cord blood (UCB) could be beneficial for this group. The aims of this study were: (i) to determine the RBC transfusion needs in infants <32 weeks in Hospital Clinic of Barcelona; (ii) to identify the target GA group that would benefit most from UCB transfusion; and (iii) to assess the current availability of UCB as a potential source of RBC transfusion for these premature infants in our tertiary referral blood bank.
Material and methods - A retrospective observational study was performed on infants born at <32 weeks GA, divided into two groups: (i) extremely low gestational age neonates (ELGAN) (from 230 to 276 weeks) and (ii) very preterm neonates (VPN) (from 280 to 316 weeks). Their complications and transfusion rates were compared. Processing and availability of UCB samples in the reference blood bank were assessed.
Results – Overall, 1,651 infants <32 weeks GA were admitted in the study period. While 12.5% of VPN received at least one RBC transfusion, the percentage increased to 60% among the ELGAN. Retinopathy of prematurity and bronchopulmonary dysplasia were diagnosed more frequently in the ELGAN group (p<0.001) than in the VPN group. The annual average volume of RBC transfusion in our study group was 1.35 L (95% CI: 1.07-1.64). The reference blood bank was able to produce 16 L (95% CI: 14-18) of UCB-RBC per year. Conclusion - Considering the data obtained about RBC transfusion needs and morbidities, the ELGAN group has been identified as the target group that would benefit most from UCB-RBC transfusions. We have demonstrated that our blood bank is able to produce enough RBC from UCB. Randomised control trials are warranted to study the potential benefits of UCB compared to adult blood for RBC transfusions.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
61 - Medicina
Palabras clave
Nadó neonatal
Extremadament prematur
Transfusió
Hemoglobina fetal
Recién nacido
Extremadamente prematuro
Transfusión
Hemoglobina fetal
Neonatal infant
Extremely premature
Transfusion
Foetal haemoglobin
Páginas
8
Publicado por
SIMTI
Colección
19
Publicado en
Blood Transfusion
Citación
García González, Elsa; Alsina Casanova, Miguel; Samarkanova, Dinara [et al.]. Feasibility of umbilical cord blood as a source of red blood cell transfusion in preterm infants. Blood Transfusion, 2021, 6. Disponible en: <https://www.bloodtransfusion.it/bt/article/view/55>. Fecha de acceso: 7 feb. 2024. DOI: 10.2450/2020.0169-20
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