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CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non-associative learning
dc.contributor.author | Iborra-Lázaro, Guillermo | |
dc.contributor.author | Djebari, Souhail | |
dc.contributor.author | Sánchez-Rodríguez, Irene | |
dc.contributor.author | Gratacòs-Batlle, Esther | |
dc.contributor.author | Sánchez-Fernández, Nuria | |
dc.contributor.author | Radošević, Marija | |
dc.contributor.author | Casals, Núria | |
dc.contributor.author | Navarro-López, Juan de Dios | |
dc.contributor.author | Soto del Cerro, David | |
dc.contributor.author | Jiménez-Díaz, Lydia | |
dc.date.accessioned | 2023-11-07T11:04:59Z | |
dc.date.available | 2023-11-07T11:04:59Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Iborra-Lázaro, Guillermo; Djebari, Souhail; Sánchez-Rodríguez, Irene [et al.]. CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non-associative learning. The Journal of Physiology, 2023, 16, p. 3533-3556. Disponible en: <https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP284248>. Fecha de acceso: 7 nov 2023. DOI: 10.1113/JP284248 | ca |
dc.identifier.issn | 0022-3751 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/3858 | |
dc.description.abstract | Carnitine palmitoyltransferase 1c (CPT1C) is a neuron-specific protein widely distributed throughout the CNS and highly expressed in discrete brain areas including the hypothalamus, hippocampus, amygdala and different motor regions. Its deficiency has recently been shown to disrupt dendritic spine maturation and AMPA receptor synthesis and trafficking in the hippocampus, but its contribution to synaptic plasticity and cognitive learning and memory processes remains mostly unknown. Here, we aimed to explore the molecular, synaptic, neural network and behavioural role of CPT1C in cognition-related functions by using CPT1C knockout (KO) mice. CPT1C-deficient mice showed extensive learning and memory deficits. The CPT1C KO animals exhibited impaired motor and instrumental learning that seemed to be related, in part, to locomotor deficits and muscle weakness but not to mood alterations. In addition, CPT1C KO mice showed detrimental hippocampus-dependent spatial and habituation memory, most probably attributable to inefficient dendritic spine maturation, impairments in long-term plasticity at the CA3–CA1 synapse and aberrant cortical oscillatory activity. In conclusion, our results reveal that CPT1C is not only crucial for motor function, coordination and energy homeostasis, but also has a crucial role in the maintenance of learning and memory cognitive functions. | en |
dc.format.extent | 24 | ca |
dc.language.iso | eng | ca |
dc.publisher | Wiley | ca |
dc.relation.ispartof | The Journal of Physiology | ca |
dc.relation.ispartofseries | 16 | |
dc.rights | © 2023 The Authors.The Journal of Physiologypublished by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, whichpermits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and nomodifications or adaptations are made. | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.other | CPT1C | ca |
dc.subject.other | Ex vivo | ca |
dc.subject.other | Prova d'habituació | ca |
dc.subject.other | Hipocamp | ca |
dc.subject.other | In vivo | ca |
dc.subject.other | Activitat locomotora | ca |
dc.subject.other | Potenciació a llarg termini | ca |
dc.subject.other | Ratolí | ca |
dc.subject.other | Nova ubicació d'objectes | ca |
dc.subject.other | Condicionament operant | ca |
dc.subject.other | Activitat oscil·latòria | ca |
dc.subject.other | CPT1C | es |
dc.subject.other | Ex vivo | es |
dc.subject.other | Prueba de habituación | es |
dc.subject.other | Hipocampo | es |
dc.subject.other | In vivo | es |
dc.subject.other | Actividad locomotora | es |
dc.subject.other | Potenciación a largo plazo | es |
dc.subject.other | Ratón | es |
dc.subject.other | Localización de objetos novedosos | es |
dc.subject.other | Condicionamiento operante | es |
dc.subject.other | Actividad oscilatoria | es |
dc.subject.other | CPT1C | en |
dc.subject.other | Ex vivo | en |
dc.subject.other | Habituation test | en |
dc.subject.other | Hippocampus | en |
dc.subject.other | In vivo | en |
dc.subject.other | Locomotor activity | en |
dc.subject.other | Long-term potentiation | en |
dc.subject.other | Mouse | en |
dc.subject.other | Novel objectlocation | en |
dc.subject.other | Operant conditioning | en |
dc.subject.other | Oscillatory activity | en |
dc.title | CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non-associative learning | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.identifier.doi | https://dx.doi.org/10.1113/JP284248 | ca |
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