dc.contributor.author | Fagundes Donadio, Márcio Vinícius | |
dc.contributor.author | Amor Barbosa, Marta | |
dc.contributor.author | Vendrusculo, Fernanda Maria | |
dc.contributor.author | Iturriaga Ramirez, Tamara | |
dc.contributor.author | Santana-Sosa, Elena | |
dc.contributor.author | Sanz-Santiago, Veronica | |
dc.contributor.author | Perez-Ruiz, Margarita | |
dc.date.accessioned | 2023-09-22T13:38:44Z | |
dc.date.available | 2023-09-22T13:38:44Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Fagundes Donadio, Márcio Vinícius; Amor Barbosa, Marta; Vendrusculo, Fernanda Maria [et al.]. Mechanisms of ventilatory limitation to maximum exercise in children and adolescents with chronic airway diseases. Pediatric Pulmonology, 2023, p. 1-10. Disponible en: <https://onlinelibrary.wiley.com/doi/10.1002/ppul.26659>. Fecha de acceso: 22 sep. 2023. DOI: 10.1002/ppul.26659 | ca |
dc.identifier.issn | 1099-0496 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/3823 | |
dc.description.abstract | Introduction: Exercise intolerance is common in chronic airway diseases (CAD), but its mechanisms are still poorly understood. The aim of this study was to evaluate exercise capacity and its association with lung function, ventilatory limitation, and ventilatory efficiency in children and adolescents with cystic fibrosis (CF) and asthma when compared to healthy controls. Methods: Cross-sectional study including patients with mild-to-moderate asthma, CF and healthy children and adolescents. Anthropometric data, lung function (spirometry) and exercise capacity (cardiopulmonary exercise testing) were evaluated. Primary outcomes were peak oxygen consumption (VO2peak), forced expiratory volume in 1 s (FEV1), breathing reserve (BR), ventilatory equivalent for oxygen consumption (VE/VO2) and for carbon dioxide production (VE/VCO2), both at the ventilatory threshold (VT1) and peak exercise. Results: Mean age of 147 patients included was 11.8 ± 3.0 years. There were differences between asthmatics and CF children when compared to their healthy peers for anthropometric and lung function measurements. Asthmatics showed lower VO2peak when compared to both healthy and CF subjects, although no differences were found between healthy and CF patients. A lower BR was found when CF patients were compared to both healthy and asthmatic. Both CF and asthmatic patients presented higher values for VE/VO2 and VE/VCO2 at VT1 when compared to healthy individuals. For both VE/VO2 and VE/VCO2 at peak exercise CF patients presented higher values when compared to their healthy peers. Conclusion: Patients with CF achieved good exercise capacity despite low ventilatory efficiency, low BR, and reduced lung function. However, asthmatics reported reduced cardiorespiratory capacity and normal ventilatory efficiency at peak exercise. These results demonstrate differences in the mechanisms of ventilatory limitation to maximum exercise testing in children and adolescents with CAD. | en |
dc.format.extent | 10 | ca |
dc.language.iso | eng | ca |
dc.publisher | John Wiley & Sons | ca |
dc.relation.ispartof | Pediatric Pulmonology | ca |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in anymedium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.© 2023 The Authors.Pediatric Pulmonologypublished by Wiley Periodicals LLC. | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.other | Asma | ca |
dc.subject.other | Reserva respiratòria | ca |
dc.subject.other | Producció de diòxid de carboni | ca |
dc.subject.other | Fibrosi quística | ca |
dc.subject.other | Equivalent al consum d'oxigen | ca |
dc.subject.other | Asma | es |
dc.subject.other | Reserva respiratoria | es |
dc.subject.other | Producción de dióxido de carbono | es |
dc.subject.other | Fibrosis quística | es |
dc.subject.other | Equivalente al consumo de oxígeno | es |
dc.subject.other | Asthma | en |
dc.subject.other | Breathing reserve | en |
dc.subject.other | Carbon dioxide production | en |
dc.subject.other | Cystic fibrosis | en |
dc.subject.other | Equivalent for oxygen consumption | en |
dc.title | Mechanisms of ventilatory limitation to maximum exercise in children and adolescents with chronic airway diseases | en |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 61 | ca |
dc.subject.udc | 616.2 | ca |
dc.identifier.doi | https://dx.doi.org/10.1002/ppul.26659 | ca |