Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk
Autor/a
Valassi, Elena
González Fernández, Pedro
Yañez, Francisca
Data de publicació
2023ISSN
1664-2392
Resum
Background: Patients with Cushing’s disease (CD) in remission maintain an increased cardiovascular risk. Impaired characteristics of gut microbiome (dysbiosis) have been associated with several cardiometabolic risk factors. Methods: Twenty-eight female non-diabetic patients with CD in remission with a mean ± SD) age of 51 ± 9 years, mean ( ± SD) BMI, 26 ± 4, median (IQR) duration of remission, 11(4) years and 24 gender-, age, BMI–matched controls were included. The V4 region of the bacterial 16S rDNA was PCR amplified and sequenced to analyse microbial alpha diversity (Chao 1 index, observed number of species, Shannon index) and beta diversity analysis through the Principal Coordinates Analysis (PCoA) of weighted and unweighted UniFrac distances. Inter-group difference in microbiome composition was analysed using MaAsLin2. Results: The Chao 1 index was lower in CD as compared with controls (Kruskal-Wallis test, q = 0.002), indicating lower microbial richness in the former. Beta diversity analysis showed that faecal samples from CS patients clustered together and separated from the controls (Adonis test, p<0.05). Collinsella, a genus form of the Actinobacteria phylum was present in CD patients only, whereas Sutterella, a genus from Proteobacteria phylum, was scarcely detectable/undetectable in CD patients as well as Lachnospira, a genus of the Lachnospiraceae family of the Firmicutes phylum. In CS, the Chao 1 index was associated with fibrinogen levels and inversely correlated with both triglyceride concentrations and the HOMA-IR index (p<0.05). Conclusions: Patients with CS in remission have gut microbial dysbiosis which may be one of the mechanisms whereby cardiometabolic dysfunctions persist after “cure”.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
61 - Medicina
616.3 - Patologia de l'aparell digestiu. Odontologia
Paraules clau
Malaltia de Cushing
Microbiota
Risc cardiovascular
Triglicèrids
Fibrinogen
Enfermedad de Cushing
Microbiota
Riesgo cardiovascular
Triglicéridos
Fibrinógeno
Cushing's disease
Microbiota
Cardiovascular risk
Triglycerides
Fibrinogen
Pàgines
10
Publicat per
Frontiers Media
Col·lecció
14
Publicat a
Frontiers in Endocrinology
Citació
Valassi, Elena; Manichanh, Chaysavanh; Amodru, Vincent [et al.]. Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk. Frontiers in Endocrinology, 2023, 14, 1074757. Disponible en: <https://www.frontiersin.org/articles/10.3389/fendo.2023.1074757/full>. Fecha de acceso: 19 sep. 2023. DOI: 10.3389/fendo.2023.1074757
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Drets
© 2023 Valassi, Manichanh, Amodru, Fernández, Gaztambide, Yañez, Martel-Duguech, Puig-Domingo and Webb. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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