Association of nine pathobionts with periodontitis in four South American and European countries
Autor/a
Contreras, María José
Mendoza, Gerardo
Nart, Jose
Data de publicació
2023ISSN
2000-2297
Resum
Aim: Our aim was to compare the prevalence and load of nine pathobionts in subgingival samples of healthy individuals and periodontitis patients from four different countries. Methods: Five hundred and seven subgingival biofilm samples were collected from healthy subjects and periodontitis patients in Belgium, Chile, Peru and Spain. The prevalence and load of Eubacterium brachy, Filifactor alocis, Fretibacterium fastidiosum, Porphyromonas endodontalis, Porphyromonas gingivalis, Selenomonas sputigena, Treponema denticola, Tannerella forsythia and Treponema socranskii were measured by quantitative PCR. Results: The association with periodontitis of all species, except for T. socranskii, was confirmed in all countries but Peru, where only P. endodontalis, P. gingivalis and T. denticola were found to be significantly associated. Moreover, most species showed higher loads at greater CAL and PPD, but not where there was BOP. Through Principal Component Analysis, samples showed clearly different distributions by diagnosis, despite observing a smaller separation in Peruvian samples. Conclusions: Unlike prevalence, relative load was found to be a reliable variable to discriminate the association of the species with periodontitis. Based on this, F. alocis, P. endodontalis, P. gingivalis, T. denticola and T. forsythia may be biomarkers of disease in Belgium, Chile and Spain, due to their significantly higher abundance in periodontitis patients.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
616.3 - Patologia de l'aparell digestiu. Odontologia
Paraules clau
Càrrega bacteriana
Biomarcador
Patobiont
Prevalença
PCR quantitativa
Especificitat d'espècie
Carga bacteriana
Biomarcador
Patobionte
Predominio
PCR cuantitativa
Especificidad de especie
Bacterial load
Biomarker
Pathobiont
Prevalence
Quantitative PCR
Species specificity
Pàgines
10
Publicat per
Journal of Oral Microbiology
Col·lecció
15
Publicat a
Journal of Oral Microbiology
Citació
Àlvarez Juste, Gerard; Arredondo, Alexandre; Isabal Pueyo, Sergio [et al.]. Association of nine pathobionts with periodontitis in four South American and European countries. Journal of Oral Microbiology, 2023, 15(1), 2188630. Disponible en: <https://www.tandfonline.com/doi/full/10.1080/20002297.2023.2188630>. Fecha de acceso: 31 mar. 2023. DOI: 10.1080/20002297.2023.2188630
Enllaç al document relacionat
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Odontologia [237]
Drets
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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