Central regulation of brown fat thermogenesis in response to saturated or unsaturated long-chain fatty acids
Autor/a
Fosch Masllovet, Anna
Rodríguez García, Maria
Miralpeix , Cristina
Zagmutt, Sebastián
Larrañaga Fernandez, Maite
Reguera, Ana Cristina
Garcia-Chica, Jesus
Herrero, Laura
Serra, Dolors
Casals, Nuria
Rodriguez-Rodriguez, Rosalia
Fecha de publicación
2023ISSN
1422-0067
Resumen
Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown adipose tissue (BAT) axis and the underlying mechanisms have remained largely unclear. Our aim was to characterize the main molecular pathways involved in the hypothalamic regulation of BAT thermogenesis in response to LCFA with different lengths and degrees of saturation. One-week administration of high-fat diet enriched in monounsaturated FA led to higher BAT thermogenesis compared to a saturated FA-enriched diet. Intracerebroventricular infusion of oleic and linoleic acids upregulated thermogenesis markers and temperature in brown fat of mice, and triggered neuronal activation of paraventricular (PaV), ventromedial (VMH) and arcuate (ARC) hypothalamic nuclei, which was not found with saturated FAs. The neuron-specific protein carnitine palmitoyltransferase 1-C (CPT1C) was a crucial effector of oleic acid since the FA action was blunted in CPT1C-KO mice. Moreover, changes in the AMPK/ACC/malonyl-CoA pathway and fatty acid synthase expression were evoked by oleic acid. Altogether, central infusion of unsaturated but not saturated LCFA increases BAT thermogenesis through CPT1C-mediated sensing of FA metabolism shift, which in turn drive melanocortin system activation. These findings add new insight into neuronal circuitries activated by LCFA to drive thermogenesis.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
61 - Medicina
616.4 - Patología del sistema linfático, órganos hematopoyéticos, endocrinos
Palabras clave
Àcids grassos de cadena llarga
Hipotàlem
Termogènesi
Teixit adipós marró
CPT1C
Obesitat
Ácidos grasos de cadena larga
Hipotálamo
Termogénesis
Tejido adiposo pardo
CPT1C
Obesidad
Long-chain fatty acids
Hypothalamus
Thermogenesis
Brown adipose tissue
CPT1C
Obesity
Páginas
18
Publicado por
MDPI
Colección
24; 2
Publicado en
International Journal of Molecular Sciences
Citación
Fosch Masllovet, Anna; Rodríguez García, Maria; Miralpeix, Cristina [et al.]. Central regulation of brown fat thermogenesis in response to saturated or unsaturated long-chain fatty acids. International Journal of Molecular Sciences, 2023, 24(2), 1697. Disponible en: <https://www.mdpi.com/1422-0067/24/2/1697>. Fecha de acceso: 7 feb. 2023. DOI: 10.3390/ijms24021697
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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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