Variation in nicotine metabolization according to biological factors and type of nicotine consumer
Autor/a
Pérez-Martín, Hipólito
Lidón-Moyano, Cristina
Fu, Marcela
Pérez Ortuño, Raúl
Ballbè, Montse
Martín-Sánchez, Juan Carlos
Pascual, José A.
Fernández, Esteve
Martínez-Sánchez, Jose M.
Data de publicació
2023ISSN
2227-9032
Resum
This study aims to describe the nicotine metabolite ratio among tobacco smokers and electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a longitudinal and a cross-sectional study of the adult population from the city of Barcelona. The final sample included information on 166 smokers, 164 e-cigarettes users with nicotine, 41 e-cigarette users without nicotine, 95 dual users (users of both products), and 508 nonusers. We used log-linear models to control for the potential confounding effect of the daily number of cigarettes smoked. Salivary nicotine metabolic rate assessment included the rate of nicotine metabolism (cotinine/nicotine) and the nicotine metabolite ratio (trans-3′-hydroxycotinine/cotinine). Exclusive users of e-cigarette without nicotine have the lowest rate of nicotine metabolism (Geometric mean: 0.08, p-values < 0.001) while cigarette smokers have the highest (Geometric mean: 2.08, p-values < 0.001). Nonusers have lower nicotine metabolic rate than cigarette smokers (Geometric means: 0.23 vs. 0.18, p-value < 0.05). Younger individuals (18–44 years) have a higher rate of nicotine metabolism than older individuals (45–64 years and 65–89) (Geometric means: 0.53 vs. 0.42 and 0.31, respectively, p-values < 0.01) and individuals with lower body mass index (21–25 kg/m2) have a higher rate of nicotine metabolism than the rest (26–30 kg/m2 and 31–60 kg/m2) (Geometric means: 0.52 vs. 0.35 and 0.36, respectively-values < 0.01). Nicotine metabolic rates are useful biomarkers when reporting smoking status and biological differences between individuals.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
61 - Medicina
616.2 - Patologia de l'aparell respiratori
Paraules clau
Biomarcador
Cotinina
Cigarreta electrònica
Nicotina
Fumar
Nicotina al metabolisme
Biomarcador
Cotinina
Cigarrillo electrónico
Nicotina
Nicotina en el metabolismo
Fumar
Biomarker
Cotinine
Electronic cigarette
Nicotine
Nicotine metabolism
Smoking
Pàgines
11
Publicat per
MDPI
Col·lecció
11; 2
Publicat a
Healthcare
Citació
Pérez-Martín, Hipólito; Lidón-Moyano, Cristina; González-Marrón, Adrián [et al.]. Variation in nicotine metabolization according to biological factors and type of nicotine consumer. Healthcare, 2023, 11(2), 179. Disponible en: <https://www.mdpi.com/2227-9032/11/2/179>. Fecha de acceso: 6 feb. 2023. DOI: 10.3390/healthcare11020179
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Drets
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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