Regulation of actin dynamics during structural plasticity of dendritic spines: signaling messengers and actin-binding proteins
Autor/a
Borovac, Jelena
Bosch, Miquel
Okamoto, Kenichi
Data de publicació
2018-09ISSN
1044-7431
Resum
Activity-dependent plasticity of synaptic structure and function plays an essential role in neuronal development and in cognitive functions including learning and memory. The formation, maintenance and modulation of dendritic spines are mainly controlled by the dynamics of actin filaments (F-actin) through interaction with various actin-binding proteins (ABPs) and postsynaptic signaling messengers. Induction of long-term potentiation (LTP) triggers a cascade of events involving Ca2+ signaling, intracellular pathways such as cAMP and cGMP, and regulation of ABPs such as CaMKII, Cofilin, Aip1, Arp2/3, α-actinin, Profilin and Drebrin. We review here how these ABPs modulate the rate of assembly, disassembly, stabilization and bundling of F-actin during LTP induction. We highlight the crucial role that CaMKII exerts in both functional and structural plasticity by directly coupling Ca2+ signaling with F-actin dynamics through the β subunit. Moreover, we show how cAMP and cGMP second messengers regulate postsynaptic structural potentiation. Brain disorders such as Alzheimer's disease, schizophrenia or autism, are associated with alterations in the regulation of F-actin dynamics by these ABPs and signaling messengers. Thus, a better understanding of the molecular mechanisms controlling actin cytoskeleton can provide cues for the treatment of these disorders.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
61 - Medicina
616.89 - Psiquiatria. Psicopatologia
Paraules clau
Plasticitat estructural
LTP
Actina
Espines dendrítiques
CaMKII
cAMP
cGMP
Plasticidad estructural
LTP
Actina
Espinas dendríticas
CaMKII
cAMP
cGMP
Enfermedad de alzheimer esquizofrenia
Malaltia d'alzheimer equizofrènia
Structural plasticity
LTP
Actin
Dendritic spines
CaMKII
cAMP
cGMP
Alzheimer's disease schizophrenia
Pàgines
9
Publicat per
Elsevier
Col·lecció
91
Publicat a
Molecular and Cellular Neuroscience
Citació
Borovac, Jelena; Bosch, Miquel; Okamoto, Kenichi. Regulation of actin dynamics during structural plasticity of dendritic spines: signaling messengers and actin-binding proteins. Molecular and Cellular Neuroscience, 2018, 91, p. 122-130. Disponible en: <https://www.sciencedirect.com/science/article/pii/S1044743117304177?via%3Dihub>. Fecha de acceso: 18 ene. 2022. DOI: 10.1016/j.mcn.2018.07.001.
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Drets
© 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com https://creativecommons.org/licenses/by-nc-nd/4.0/