Effect of the size of titanium particles released from dental implants on immunological response
Autor/a
Callejas, Juan Antonio
Data de publicació
2022ISSN
1422-0067
Resum
The techniques used in oral implantology to remove bacterial biofilm from the surface of implants by machining the titanium surface (implantoplasty) or by placing rough dental implants through friction with the cortical bone generate a large release of particles. In this work, we performed a simulation of particle generation following clinical protocols. The particles were characterized for commercially pure titanium with particle sizes of 5, 10, 15, and 30 μm. The aim was to determine the effect of particle size and chemical composition of the implant on the immune response. For this purpose, their morphology and possible contamination were characterized by scanning electron microscopy and X-ray microanalysis. In addition, the granulometry, specific surface area, release of metal ions into the medium, and studies of cytocompatibility, gene expression, and cytokine release linked to the inflammatory process were studied. The release of ions for titanium particles showed levels below 800 ppb for all sizes. Smaller particle sizes showed less cytotoxicity, although particles of 15 μm presented higher levels of cytocompatibility. In addition, inflammatory markers (TNFα and Il-1β) were higher compared to larger titanium. Specifically, particles of 15 μm presented a lower proinflammatory and higher anti-inflammatory response as characterized by gene expression and cytokine release, compared to control or smaller particles. Therefore, in general, there is a greater tendency for smaller particles to produce greater toxicity and a greater proinflammatory response.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
616.3 - Patologia de l'aparell digestiu. Odontologia
Paraules clau
Titani
Implantoplàstia
Implants dentals
Citotoxicitat
Reacció inflamatòria
Titanio
Implantoplastia
Implantes dentales
Citotoxicidad
Reacción inflamatoria
Titanium
Implantoplasty
Dental implants
Cytotoxicity
Inflammatory reaction
Pàgines
13
Publicat per
MDPI
Col·lecció
23
Publicat a
International Journal of Molecular Sciences
Citació
Callejas, Juan Antonio; Gil Mur, Francisco Javier; Brizuela Velasco, Aritza [et al.]. Effect of the size of titanium particles released from dental implants on immunological response. International Journal of Molecular Sciences, 2022, 23(13), 7333. Disponible en: <https://www.mdpi.com/1422-0067/23/13/7333>. Fecha de acceso: 2 nov. 2022. DOI: 10.3390/ijms23137333
Enllaç al document relacionat
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Drets
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