Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants

Toledano-Serrabona, Jorge; Bosch Canals, Begoña Maria; Díez-Tercero, Leire; Gil Mur, Francisco Javier; Camps Font, Octavi; Valmaseda-Castellon, Eduard; Gay Escoda, Cosme; Sánchez-Garcés, Mª Ángeles

dc.contributor.author	Toledano-Serrabona, Jorge
dc.contributor.author	Bosch Canals, Begoña Maria
dc.contributor.author	Díez-Tercero, Leire
dc.contributor.author	Gil Mur, Francisco Javier
dc.contributor.author	Camps Font, Octavi
dc.contributor.author	Valmaseda-Castellon, Eduard
dc.contributor.author	Gay Escoda, Cosme
dc.contributor.author	Sánchez-Garcés, Mª Ángeles
dc.date.accessioned	2022-10-20T15:02:21Z
dc.date.available	2022-10-20T15:02:21Z
dc.date.issued	2022
dc.identifier.citation	Toledano-Serrabona, Jorge; Bosch Canals, Begoña Maria; Díez-Tercero, Leire [et al.]. Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants. Scientific Reports, 2022, 12, 15790. Disponible en: <https://www.nature.com/articles/s41598-022-20100-2>. Fecha de acceso: 20 oct. 2022. DOI: 10.1038/s41598-022-20100-2	ca
dc.identifier.issn	2045-2322	ca
dc.identifier.uri	http://hdl.handle.net/20.500.12328/3460
dc.description.abstract	Implantoplasty is a mechanical decontamination technique that consists of removing the threads and polishing and smoothing the dental implant surface. During implantoplasty there is a large release of titanium metal particles that might provoke a proinflammatory response and reduce the viability of osteogenic cells. We analyze the inflammatory and osteogenic response induced by Ti6Al4V particles released during implantoplasty and by as-received commercially pure Ti particles. Macrophages stimulated with metal particles obtained by implantoplasty and with as-received Ti particles showed an increased proinflammatory expression of TNF-α and a decreased expression of TGF-β and CD206. Regarding cytokine release, there was an increase in IL-1β, while IL-10 decreased. The osteogenic response of Ti6Al4V extracts showed a significant decrease in Runx2 and OC expression compared to the controls and commercially pure Ti extracts. There were no relevant changes in ALP activity. Thus, implantoplasty releases metal particles that seems to induce a pro-inflammatory response and reduce the expression of osteogenic markers.	en
dc.format.extent	11	ca
dc.language.iso	eng	ca
dc.publisher	Springer Nature	ca
dc.relation.ispartof	Scientific Reports	ca
dc.relation.ispartofseries	12
dc.relation.uri	https://www.nature.com/articles/s41598-022-20100-2	ca
dc.rights	This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.	en
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.other	Implants dentals	ca
dc.subject.other	Periimplantitis	ca
dc.subject.other	Implantes dentales	es
dc.subject.other	Periimplantitis	es
dc.subject.other	Dental implants	en
dc.subject.other	Peri-implantitis	en
dc.title	Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants	en
dc.type	info:eu-repo/semantics/article	ca
dc.description.version	info:eu-repo/semantics/publishedVersion	ca
dc.rights.accessLevel	info:eu-repo/semantics/openAccess
dc.embargo.terms	cap	ca
dc.subject.udc	616.3	ca
dc.identifier.doi	https://dx.doi.org/10.1038/s41598-022-20100-2	ca

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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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