Hormone-control regions mediate steroid receptor–dependent genome organization
Visualitza/Obre
Autor/a
Le Dily, François
Vidal, Enrique
Cuartero, Yasmina
Quilez Oliete, Javier
Nacht, A. Silvina
Vicent, Guillermo P.
Carbonell-Caballero, José
Sharma, Priyanka
Villanueva-Cañas, José Luis
Ferrari, Roberto
De Llobet, Lara Isabel
Verde, Gaetano
Wright, Roni H.G.
Beato, Miguel
Data de publicació
2019ISSN
1088-9051
Resum
In breast cancer cells, some topologically associating domains (TADs) behave as hormonal gene regulation units, within which gene transcription is coordinately regulated in response to steroid hormones. Here we further describe that responsive TADs contain 20- to 100-kb-long clusters of intermingled estrogen receptor (ESR1) and progesterone receptor (PGR) binding sites, hereafter called hormone-control regions (HCRs). In T47D cells, we identified more than 200 HCRs, which are frequently bound by unliganded ESR1 and PGR. These HCRs establish steady long-distance inter-TAD interactions between them and organize characteristic looping structures with promoters in their TADs even in the absence of hormones in ESR1+-PGR+ cells. This organization is dependent on the expression of the receptors and is further dynamically modulated in response to steroid hormones. HCRs function as platforms that integrate different signals, resulting in some cases in opposite transcriptional responses to estrogens or progestins. Altogether, these results suggest that steroid hormone receptors act not only as hormone-regulated sequence-specific transcription factors but also as local and global genome organizers.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
English
Matèries (CDU)
61 - Medicina
616 - Patologia. Medicina clínica. Oncologia
Paraules clau
Càncer de mama
Regulació gènica hormonal
Transcripció gènica
Hormones esteroides
Estrògens
Progestina
Genoma
Cáncer de mama
Regulación génica hormonal
Transcripción génica
Hormonas esteroides
Estrógenos
Progestina
Genoma
Breast cancer
Hormonal gene regulation
Gene transcription
Steroid hormones
Estrogens
Progestin
Genome
Pàgines
12
Publicat per
Cold Spring Harbor Laboratory Press
Col·lecció
29;
Publicat a
Genome Research
Citació
Le Dily, François; Vidal, Enrique; Cuartero, Yasmina [et al.]. Hormone-control regions mediate steroid receptor-dependent genome organization. Genome Research, 2018, 29, p. 29-39. Disponible en: <https://genome.cshlp.org/content/29/1/29>. Fecha de acceso: 13 dic. 2021.
Aquest element apareix en la col·lecció o col·leccions següent(s)
- Ciències de la Salut [740]
Drets
© 2019 Le Dily et al.; Published by Cold Spring Harbor Laboratory Press This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com https://creativecommons.org/licenses/by-nc/4.0/